A Pilot study to assess the effects of beta-blockade on exercise capacity and BNP levels in patients with predominantly diastolic heart failure

south manchester university hospital nhs trust0 sites40 target enrollmentApril 21, 2005

Overview

No summary available.

Registry

who.int

Start Date

April 21, 2005

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

south manchester university hospital nhs trust

•All patients must satisfy all of the following criteria to be entered into the study.
•1\) Evidence or history of clinical heart failure.
•2\) Ejection fraction of \>45%.
•3\) Raised Plasma BNP levels.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range
•F.1\.3 Elderly (\>\=65 years) yes
•F.1\.3\.1 Number of subjects for this age range

•1\) Clinical evidence of pulmonary or peripheral oedema.
•2\) History of asthma or significant reversible chronic obstructive airways disease (reversibility in FEV1 of \> 15%)
•3\) Hypotension (BP \< 100/60\)
•4\) Significant bradycardia (heart rate \< 55 bpm), 2nd or 3rd degree AV block.
•5\) History of intolerance to beta\-blocker treatment.
•6\) Diagnosis of constrictive pericarditis.
•7\) Presence of severe peripheral vascular disease.
•10\) Myocardial infarction within 3 months prior to enrolment.
•11\) Female patients, who are pregnant, breast feeding or planning pregnancy during the course of the study.
•12\) Use of any investigational drug within 2 weeks of enrolment into the study.