Role of Beta Blocker (Drug) in Patients With Acute-on-chronic Liver Failure (liver Disease).
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Acute on Chronic Liver FailureHealth Condition 2: K721- Chronic hepatic failure
- Registration Number
- CTRI/2018/02/012024
- Lead Sponsor
- Institute of liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 136
Inclusion Criteria
1)Acute on Chronic Liver Failure as per APASL (Asian Pacific Association of Study of Liver Disease) criteria.
2)18-75 years
3)HVPG more than 12 with No/Small Esophageal varices
Exclusion Criteria
1) Bradycardia (HR < 60/ min)
2) Hypotension
3) Asthma
4) LVF
5) AKI (Acute Kidney Injury)
6) Refractory ascites
7) SBP (Spontaneous Bacterial Peritonitis)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Development of Esophageal Variceal bleedingTimepoint: during 3 months
- Secondary Outcome Measures
Name Time Method Adverse EventsTimepoint: 3 months;Improvement in liver severity scoresTimepoint: 3 month;Progression of esophageal varicesTimepoint: During 3 months;Reduction in portal pressure/LSM (Liver Stiffness Measurement)/esophageal VaricesTimepoint: 3 months;SurvivalTimepoint: 3 months;Transplant free survival/spontaneous recoveryTimepoint: 3 months