The Coastal Exposome: a Study of Sea Air Inhalation and Possible Links to Health
- Conditions
- Immune SuppressionExposure
- Interventions
- Other: change of environmentOther: no intervention
- Registration Number
- NCT06477627
- Lead Sponsor
- University Ghent
- Brief Summary
The research aims to understand oceans as crucial contributors to human health in coastal environments. Oceans produce marine spray aerosols that contain a mixture of microbiota and natural biological molecules (biogenics).
- Detailed Description
The primary outcome envisioned consists of 2 goals.
1. In this study, the first objective is to determine whether the microbiota and biogenic molecules found in sea air are also found in the nasal swabs of the participants. In this way, the investigators will gain an understanding of which sea air components are inhaled by humans and how this changes over time.
2. Second, the investigators want to get an idea of whether these inhaled sea air components have an effect on certain pathways in the human body. In the in vitro study with cell lines, effects were already seen of sea air exposure on certain pathways in the body. Now the second goal of this study, is to see if changes in immunity biomarkers (IL-6, TNF-alpha, IL-10) are seen in vivo in humans. The Investigators will do this by taking VAMS blood samples from the participants.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 67
- health participants between 18 and 50 years old
- people with a medical condition
- people younger than 18 and older than 50
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Studygroup that will move from inland to the coast for one month change of environment This group normally lives inland and live at the coast in august. We investigate the change to the coast environment reference group coast no intervention This group lives inland the whole year round reference group inland no intervention This group lives inland all year round.
- Primary Outcome Measures
Name Time Method VAMS blood samples: cytokines 4 times during the 8 week study period Cytokines (IL-6, TNF-alfa, IL-10) will be measured in blood samples to link the sea air exposure to the human health
nose swabs: respiratory microbiome and biogenics profile 4 times during the 8 week study period DNA from the nose swabs will be analysed for microbiota and biogenics on the swabs will be analysed as well, to get an idea of what molecules and microbiota from the sea air are inhaled.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ghent University
🇧🇪Ghent, Oost-Vlaanderen, Belgium