Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial
Overview
- Phase
- Phase 4
- Intervention
- Local analgesic
- Conditions
- Pain
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- pain
- Last Updated
- 11 years ago
Overview
Brief Summary
Pain after amputation is a significant problem among amputees. Phantom limb pain may appear in up to 85% of patients and is usually resistant to a wide variety of treatments.It is believed that regional anesthesia, by preventing the establishment of central sensitization, may play a role in reducing the incidence of acute and chronic pain. Therefore the investigators will compare two methods of postoperative analgesic after after amputation by their efficiency and complication.
Detailed Description
Peripheral nerve transection results in an afferent nociceptive barrage that initiates spinal cord hyperexcitability with expansion of the receptive fields of dorsal horn neurons that respond to the nearest intact afferents. These neuroplastic changes are believed to be responsible for the development of postsurgical chronic pain syndromes, including phantom limb and stump pain.At present, there are no randomized studies with sample sizes that ensure power, or blinded for end-point assessment,to support the evidence on pharmacological and non-pharmacological treatments of Pain after amputation. Consequently, our study was designed to arrive at clear conclusions about treatment efficacy and to give stronger recommendations for clinical practice.
Investigators
bo xu
associate chief physician
Guangzhou General Hospital of Guangzhou Military Command
Eligibility Criteria
Inclusion Criteria
- •Patients of American Association of anesthetists（ASA）Grade 1 or 2
- •Aged between 18 and 65 years
- •Undergoing elective total knee replacement
Exclusion Criteria
- •Mental illness can not match
- •Nerve block, epidural anesthesia contraindicated
- •People who have Slow-type arrhythmias
- •History of chronic headaches and long-term use of analgesic drugs
- •People who were postoperative consciousness, language or hearing impaired
Arms & Interventions
Local analgesic
This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
Intervention: Local analgesic
Local analgesic
This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
Intervention: ropivacaine
Intravenous analgesic
This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
Intervention: Intravenous analgesic
Intravenous analgesic
This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
Intervention: flurbiprofen
Outcomes
Primary Outcomes
pain
Time Frame: 72 hours postoperation
Up to 72 hours after operation,postoperative pain visual analogue scale(VAS) scores are used to evaluate the level of pain.
Secondary Outcomes
- Phantom pain(three months postoperation)
- complication(72 hours postoperation)