A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
- Conditions
- Metastatic Breast Cancer
- Interventions
- Registration Number
- NCT06018337
- Lead Sponsor
- DualityBio Inc.
- Brief Summary
The goal of this clinical trial is to assess the efficacy of DB-1303/BNT323 compared with investigator's choice chemotherapy in terms of progression-free survival (PFS) by blinded independent central review (BICR) in the HR+, HER2-low (immunohistochemistry \[IHC\]2+/in situ hybridization \[ISH\]- and IHC 1+) population.
- Detailed Description
The study is a Phase III, Randomized, Multi-center, Open-label study in HER2-low, HR+ metastatic breast cancer subjects whose disease has progressed on at least 2 lines of prior ET or within 6 months of first line ET + Cyclin-dependent kinase (CDK) 4/6 inhibitor in the metastatic setting. The primary purpose of the study is to determine the efficacy and safety of DB-1303/BNT323 compared with investigator's choice single agent chemotherapy in the target population. Approximately 532 subjects with HER2 IHC 2+/ISH- and IHC 1+ (HER2-low\] expression will be randomized 1:1 across approximately 255 centers globally to receive either DB-1303 or investigator's choice single agent chemotherapy (capecitabine, paclitaxel or nab-paclitaxel) until Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 defined disease progression (PD), unless there is unacceptable toxicity, withdrawal of consent, or another criterion for discontinuation is met.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 532
-
Male or female adults (defined as ≥ 18 years of age or acceptable age according to local regulations at the time of voluntarily signing of informed consent).
-
Pathologically documented breast cancer that:
-
Is advanced or metastatic
-
Has HER2-low expression (IHC 1+ or IHC 2+/ISH-) as determined by the central laboratory result.
-
Was never previously reported as HER2-positive (IHC 3+ or ISH+) as per American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines.
-
Is documented as HR+ (either estrogen receptor [ER] and/or progesterone receptor [PgR] positive [ER or PgR ≥1%]) per ASCO/CAP guidelines (Allison et al 2020).
-
Must have an adequate tumor tissue sample available for assessment of HER2 by central laboratory, in formalin fixation and paraffin embedding (FFPE) blocks based on a mandatory FFPE tumor sample preferably obtained at the time of metastatic disease or later;
-
Eastern Cooperative Oncology Group performance status of 0 or 1.
-
Must have had either:
-
Disease progression on endocrine therapy + CDK4/6 inhibitor within 6 months of starting first line treatment for metastatic disease and considered appropriate for chemotherapy as the next treatment by the investigator, OR
-
Disease progression on at least 2 previous lines of ET with or without a targeted therapy (such as CDK4/6, mammalian target of rapamycin [mTOR] or phosphoinositide 3-kinase [PI3-K] inhibitors) administered for the treatment of metastatic disease.
-
No prior chemotherapy for advanced or metastatic breast cancer. Subjects who have received chemotherapy in the neo-adjuvant or adjuvant setting are eligible, as long as they have had a disease-free interval (defined as completion of systemic chemotherapy to diagnosis of advanced or metastatic disease) of >12 months.
-
Life expectancy ≥12 weeks at screening.
-
Subjects must have at least one measurable lesion as defined per RECIST v1.1 (For bone only disease, subjects with lytic or mixed lytic bone lesions that can be measured by CT or MRI are eligible; subjects with sclerotic/osteoblastic bone lesions are not eligible).
-
Has LVEF ≥ 50% by either echocardiography (ECHO) or multiple-gated acquisition (MUGA) within 28 days before randomization.
-
Adequate organ and bone marrow function within 14 days before randomization.
-
Has adequate treatment washout period before randomization.
-
Evidence of post-menopausal status or negative serum pregnancy test for females of childbearing potential who are sexually active with a non-sterilized male partner. For women of childbearing potential, a negative result for serum pregnancy test (test must have a sensitivity of at least 25 mIU/mL) must be available at the screening visit and urine beta-human chorionic gonadotropin (β-HCG) pregnancy test prior to each administration of study treatment.
Women of childbearing potential are defined as those who are not surgically sterile (i.e., underwent bilateral salpingectomy, bilateral oophorectomy, or complete hysterectomy) or post-menopausal.
-
Female subjects of childbearing potential who are sexually active with a non-sterilized male partner must use at least one highly effective method of contraception from the time of screening and must agree to continue using such precautions for 7 months after the last dose of study treatment. Not all methods of contraception are highly effective. Abstinence is acceptable only as true abstinence when this is in line with the preferred and usual lifestyle of the subject for the duration of the study treatment and the drug washout period (7 months). Periodic abstinence (e.g., calendar ovulation, symptothermal, post ovulation methods), the rhythm method, and the withdrawal method are not acceptable methods of contraception. Female subjects must not donate ova, or retrieve for their own use, from the time of screening and throughout the study treatment period, and for at least 7 months after the last dose of study treatment. They should refrain from breastfeeding throughout this time. Preservation of ova may be considered prior to randomization in this study.
-
Non-sterilized male subjects who are sexually active with a female partner of childbearing potential must use a condom with spermicide from screening and throughout the duration of the study treatment and the washout period (4 months after the last dose of DB-1303, 6 months after the last dose of paclitaxel or nab-paclitaxel, and 3 months after the last dose of capecitabine). Abstinence is acceptable only as true abstinence when this is in line with the preferred and usual lifestyle of the subject for the duration of the study treatment and the drug washout period. Periodic abstinence (e.g., calendar ovulation, symptothermal, post ovulation methods), the rhythm method, and the withdrawal method are not acceptable methods of contraception. It is strongly recommended for the female partners of a male subject also use at least one highly effective method of contraception throughout this period. In addition, male subjects should refrain from fathering a child or donating sperm throughout the duration of the study and the washout period (4 months after the last dose of DB-1303, 6 months after the last dose of paclitaxel or nab paclitaxel, and 3 months after the last dose of capecitabine). Preservation of sperm should be considered prior to randomization in this study.
-
Must be able and willing to comply with the protocol requirements and must sign and date the informed consent form prior to any screening evaluations.
- Ineligible for all options in the investigator's choice chemotherapy arm.
- Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, uncontrolled or significant cardiovascular disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring adverse events or compromise the ability of the subject to give written informed consent.
- Clinically uncontrolled pleural effusion, ascites or pericardial effusion requiring repeated drainage, peritoneal shunt or cell-free concentrated ascites reinfusion therapy within 2 weeks prior to the randomization.
- Uncontrolled or significant cardiovascular disease
- Has a medical history of interstitial lung diseases (e.g., non-infectious interstitial pneumonia, pneumonitis, pulmonary fibrosis, and radiation pneumonitis which needs glucocorticoids and antibiotics) or current interstitial lung diseases or who are suspected to have these diseases by imaging at screening.
- Has unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved to Grade ≤ 1 or baseline or Grade ≤ 2 anemia.
- Previous treatment with anti-HER2 therapy.
- Prior treatment with antibody-drug conjugate that comprised an exatecan derivative that is a topoisomerase I inhibitor.
- Prior randomization or treatment in a previous DB-1303/BNT323 study regardless of treatment assignment.
- Has substance abuse or any other medical conditions such as psychological conditions, that may, in the opinion of the Investigator, interfere with the subject's participation in the clinical study or evaluation of the clinical study results.
- Individuals who are dependent on the Sponsor, clinical site, or Investigator (e.g., is an employee of the Sponsor or the clinical trial site, a dependent of the Investigator, or any site staff member otherwise supervised by the Investigator).
- Individuals who are committed to an institution by virtue of an order issued either by the judicial or the administrative authorities, in accordance with local regulations.
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description DB-1303/BNT323 DB-1303/BNT323 Enrolled Subjects will be randomized to receive a 8 mg/kg IV dose of DB-1303/BNT323 on Day 1 of each cycle Q3W investigator's choice single agent chemotherapy Nab-paclitaxel Enrolled Subjects will be randomized to receive investigator's choice single agent chemotherapy (capecitabine:1000 or 1250 mg/m2, Oral, Twice daily orally for 2 weeks followed by a 1-week rest period in 3-week cycles; paclitaxel：80 mg/m2， IV, Every week (QW) in 3-week cycles; or nab-paclitaxel: 100 mg/m2, IV, Every week (QW) for 3 weeks followed by a one-week rest period in 4-week cycles) until RECIST 1.1 defined disease progression (PD), unless there is unacceptable toxicity, withdrawal of consent, or another criterion for discontinuation is met. investigator's choice single agent chemotherapy Capecitabine Enrolled Subjects will be randomized to receive investigator's choice single agent chemotherapy (capecitabine:1000 or 1250 mg/m2, Oral, Twice daily orally for 2 weeks followed by a 1-week rest period in 3-week cycles; paclitaxel：80 mg/m2， IV, Every week (QW) in 3-week cycles; or nab-paclitaxel: 100 mg/m2, IV, Every week (QW) for 3 weeks followed by a one-week rest period in 4-week cycles) until RECIST 1.1 defined disease progression (PD), unless there is unacceptable toxicity, withdrawal of consent, or another criterion for discontinuation is met. investigator's choice single agent chemotherapy Paclitaxel Enrolled Subjects will be randomized to receive investigator's choice single agent chemotherapy (capecitabine:1000 or 1250 mg/m2, Oral, Twice daily orally for 2 weeks followed by a 1-week rest period in 3-week cycles; paclitaxel：80 mg/m2， IV, Every week (QW) in 3-week cycles; or nab-paclitaxel: 100 mg/m2, IV, Every week (QW) for 3 weeks followed by a one-week rest period in 4-week cycles) until RECIST 1.1 defined disease progression (PD), unless there is unacceptable toxicity, withdrawal of consent, or another criterion for discontinuation is met.
- Primary Outcome Measures
Name Time Method Progression-free survival (PFS) in the HR+, HER2-low population Up to approximately 51 months PFS by BICR according to RECIST 1.1 in the HR+, HER2-low population
- Secondary Outcome Measures
Name Time Method Overall survival (OS) in the HR+, HER2-low population Up to approximately 51 months OS in the HR+, HER2-low population
Objective response rate (ORR) in the HR+, HER2-low population Up to approximately 51 months ORR by BICR and Investigator assessment according to RECIST 1.1 in the HR+, HER2-low population
PFS by Investigator assessment Up to approximately 51 months PFS by Investigator assessment according to RECIST 1.1 in the HR+, HER2-low population
Duration of response (DoR) in the HR+, HER2-low population Up to approximately 51 months DoR by BICR and Investigator assessment according to RECIST 1.1 in the HR+, HER2-low population
Treatment-emergent adverse events (TEAEs) from the time of the subject signing the informed consent form (ICF) until the follow-up period is completed (35 days after the last dose of study treatment TEAEs per National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v5.0
Serious adverse events (SAEs) from the time of the subject signing the ICF until the follow-up period is completed (35 days after the last dose of study treatment SAEs per NCI CTCAE v5.0
Patient reported outcomes (PROs): European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) - C30 Up to approximately 51 months Change from baseline in the functioning/symptom/global quality of life (QoL) subscales of EORTC QLQ-C30. Scale scores range from 0-100. For functioning and global QoL scales, higher scores indicate better functioning or global health status. For symptom scales, higher scores indicate greater symptom burden.
Patient reported outcomes (PROs): EORTC QLQ-BR45 Up to approximately 51 months Change from baseline in the functioning/symptom subscales of EORTC QLQ-BR45. Scale scores range from 0-100. For functioning scales, higher scores indicate better functioning. For symptom scales, higher scores indicate greater symptom burden.
Patient reported outcomes (PROs): European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) Up to approximately 51 months Change from baseline in EQ-5D-5L health state utility index score and Visual Analogue Scale (VAS) score. VAS score range from 0-100, higher scores indicate better health status.
European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) Up to approximately 51 months EQ-5D-5L health state utility index score and Visual Analogue Scale (VAS) score. The change from baseline value will be reported.
Trial Locations
- Locations (185)
Research Site 1141-0
🇺🇸Tucson, Arizona, United States
Research Site 1114-0
🇺🇸Fullerton, California, United States
Research Site 1107-0
🇺🇸Los Angeles, California, United States
Research Site 1118-0
🇺🇸Orange, California, United States
Research Site 1143-0
🇺🇸Sacramento, California, United States
Research Site 1132-0
🇺🇸Santa Barbara, California, United States
Research Site 1129-0
🇺🇸Lone Tree, Colorado, United States
Research Site 1125-0
🇺🇸Palm Bay, Florida, United States
Research Site 1110-0
🇺🇸Savannah, Georgia, United States
Research Site 1124-0
🇺🇸Chicago Ridge, Illinois, United States
Research Site 1106-0
🇺🇸Merriam, Kansas, United States
Research Site 1104-0
🇺🇸Louisville, Kentucky, United States
Research Site 1122-0
🇺🇸Silver Spring, Maryland, United States
Research Site 8639-0
🇺🇸Silver Spring, Maryland, United States
Research Site 1109-0
🇺🇸Kansas City, Missouri, United States
Research Site 1111-0
🇺🇸Florham Park, New Jersey, United States
Research Site 1105-0
🇺🇸Westbury, New York, United States
Research Site 1144-0
🇺🇸Chapel Hill, North Carolina, United States
Research Site 1138-0
🇺🇸Akron, Ohio, United States
Research Site 1133-0
🇺🇸Eugene, Oregon, United States
Research Site 1126-0
🇺🇸Tigard, Oregon, United States
Research Site 1134-0
🇺🇸Broomall, Pennsylvania, United States
Research Site 1123-0
🇺🇸Horsham, Pennsylvania, United States
Research Site 1149-0
🇺🇸Knoxville, Tennessee, United States
Research Site 1102-0
🇺🇸Nashville, Tennessee, United States
Research Site 1101-0
🇺🇸Dallas, Texas, United States
Research Site 1116-0
🇺🇸Denison, Texas, United States
Research Site 1115-0
🇺🇸Houston, Texas, United States
Research Site 1117-0
🇺🇸San Antonio, Texas, United States
Research Site 1130-0
🇺🇸Salt Lake City, Utah, United States
Research Site 1108-0
🇺🇸Fairfax, Virginia, United States
Research Site 1131-0
🇺🇸Fairfax, Virginia, United States
Research Site 1127-0
🇺🇸Roanoke, Virginia, United States
Research Site 5401-0
🇦🇷Rosario, Santa Fe, Argentina
Research Site 5404-0
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Research Site 6108-0
🇦🇺Camperdown, New South Wales, Australia
Research Site 6109-0
🇦🇺Liverpool, New South Wales, Australia
Research Site 6102-0
🇦🇺Sydney, New South Wales, Australia
Research Site 6106-0
🇦🇺Birtinya, Queensland, Australia
Research Site 6101-0
🇦🇺South Brisbane, Queensland, Australia
Research Site 6107-0
🇦🇺Southport, Queensland, Australia
Research Site 6104-0
🇦🇺Townsville, Queensland, Australia
Research Site 6110-0
🇦🇺Adelaide, South Australia, Australia
Research Site 6103-0
🇦🇺Bendigo, Victoria, Australia
Research Site 6105-0
🇦🇺St. Albans, Victoria, Australia
Research Site 3201-0
🇧🇪Brussels, Belgium
Research Site 3204-0
🇧🇪Gent, Belgium
Research Site 3205-0
🇧🇪Jette, Belgium
Research Site 3203-0
🇧🇪Leuven, Belgium
Research Site 3207-0
🇧🇪Liege, Belgium
Research Site 3202-0
🇧🇪Roeselare, Belgium
Research Site 1003-0
🇨🇦Brampton, Ontario, Canada
Research Site 1001-0
🇨🇦Toronto, Ontario, Canada
Research Site 1004-0
🇨🇦Montreal, Quebec, Canada
Research Site 1005-0
🇨🇦Montreal, Quebec, Canada
Research Site 1006-0
🇨🇦Montreal, Quebec, Canada
Research Site 1002-0
🇨🇦Sherbrooke, Quebec, Canada
Research Site 8640-0
🇨🇳Hefei, Anhui, China
Research Site 8614-0
🇨🇳Hefei, Anhui, China
Research Site 8601-0
🇨🇳Beijing, Beijing, China
Research Site 8625-0
🇨🇳Beijing, Beijing, China
Research Site 8627-0
🇨🇳Chongqing, Chongqing, China
Research Site 8651-0
🇨🇳Fuzhou, Fujian, China
Research Site 8638-0
🇨🇳Xiamen, Fujian, China
Research Site 8630-0
🇨🇳Lanzhou, Gansu, China
Research Site 8604-0
🇨🇳Guangzhou, Guangdong, China
Research Site 8628-0
🇨🇳Guangzhou, Guangdong, China
Research Site 8621-0
🇨🇳Huizhou, Guangdong, China
Research Site 8622-0
🇨🇳Zhuhai, Guangdong, China
Research Site 8615-0
🇨🇳Nanning, Guangxi, China
Research Site 8629-0
🇨🇳Baoding, Hebei, China
Research Site 8645-0
🇨🇳Shijiazhuang, Hebei, China
Research Site 8619-0
🇨🇳Harbin, Heilongjiang, China
Research Site 8649-0
🇨🇳Anyang, Henan, China
Research Site 8609-0
🇨🇳Luoyang, Henan, China
Research Site 8648-0
🇨🇳Weihui, Henan, China
Research Site 8605-0
🇨🇳Zhengzhou, Henan, China
Research Site 8623-0
🇨🇳Zhengzhou, Henan, China
Research Site 8637-0
🇨🇳Wuhan, Hubei, China
Research Site 8608-0
🇨🇳Wuhan, Hubei, China
Research Site 8633-0
🇨🇳Xiangyang, Hubei, China
Research Site 8635-0
🇨🇳Changsha, Hunan, China
Research Site 8654-0
🇨🇳Yongzhou, Hunan, China
Research Site 8646-0
🇨🇳Huai'an, Jiangsu, China
Research Site 8607-0
🇨🇳Nanjing, Jiangsu, China
Research Site 8624-0
🇨🇳Xuzhou, Jiangsu, China
Research Site 8631-0
🇨🇳Nanchang, Jiangxi, China
Research Site 8612-0
🇨🇳Changchun, Jilin, China
Research Site 8618-0
🇨🇳Changchun, Jilin, China
Research Site 8644-0
🇨🇳Changchun, Jilin, China
Research Site 8636-0
🇨🇳Dalian, Liaoning, China
Research Site-8636-0
🇨🇳Dalian, Liaoning, China
Research Site 8643-0
🇨🇳Shenyang, Liaoning, China
Research Site 8642-0
🇨🇳Shenyang, Liaoning, China
Research Site 8634-0
🇨🇳Jinan, Shandong, China
Research Site 8613-0
🇨🇳Jining, Shandong, China
Research Site 8610-0
🇨🇳Linyi, Shandong, China
Research Site 8650-0
🇨🇳Weihai, Shandong, China
Research Site 8603-0
🇨🇳Shanghai, Shanghai, China
Research Site 8602-0
🇨🇳Shanghai, Shanghai, China
Research Site 8611-0
🇨🇳Xi'an, Shanxi, China
Research Site 8606-0
🇨🇳Chengdu, Sichuan, China
Research Site 8626-0
🇨🇳Neijiang, Sichuan, China
Research Site 8647-0
🇨🇳Zigong, Sichuan, China
Research Site 8617-0
🇨🇳Tianjin, Tianjin, China
Research Site 8616-0
🇨🇳Urumqi, Xinjiang, China
Research Site 8632-0
🇨🇳Kunming, Yunnan, China
Research Site 8652-0
🇨🇳Hangzhou, Zhejiang, China
Research Site 8620-0
🇨🇳Hangzhou, Zhejiang, China
Research Site 8641-0
🇨🇳Hangzhou, Zhejiang, China
Research Site 3311-0
🇫🇷Marseille cedex 20, Bouches-du-Rhône, France
Research Site 3303-0
🇫🇷La Rochelle cedex, Charente Maritime, France
Research Site 3312-0
🇫🇷Besancon Cedex, Doubs, France
Research Site 3308-0
🇫🇷Nimes, Gard, France
Research Site 3314-0
🇫🇷Bordeaux, Gironde, France
Research Site 3305-0
🇫🇷Toulouse cedex 09, Haute Garonne, France
Research Site 3309-0
🇫🇷Limoges, Haute Vienne, France
Research Site 3304-0
🇫🇷Montpellier, Herault, France
Research Site 3310-0
🇫🇷Saint Herblain, Loire Atlantique, France
Research Site 3301-0
🇫🇷Angers Cedex 2, Maine Et Loire, France
Research Site 3315-0
🇫🇷Lille cedex, Nord, France
Research Site 3306-0
🇫🇷Bayonne cedex, Pyrenees Atlantiques, France
Research Site 3318-0
🇫🇷Pierre Benite cedex, Rhone, France
Research Site 3313-0
🇫🇷Rouen, Seine Maritime, France
Research Site 3307-0
🇫🇷Avignon Cedex 9, Vaculuse, France
Research Site 3302-0
🇫🇷Creteil Cedex, Val De Marne, France
Research Site 3316-0
🇫🇷Paris, France
Research Site 4904-0
🇩🇪Bottrop, Nordrhein Westfalen, Germany
Research Site 8501-0
🇭🇰Hong Kong, Hong Kong
Research Site 8503-0
🇭🇰Hong Kong, Hong Kong
Research Site 8502-0
🇭🇰Hong Kong, Hong Kong
Research Site 8505-0
🇭🇰Hong Kong, Hong Kong
Research Site 3603-0
🇭🇺Budapest, Hungary
Research Site 3606-0
🇭🇺Gyor, Hungary
Research Site 3604-0
🇭🇺Kecskemet, Hungary
Research Site 3602-0
🇭🇺Salgotarjan, Hungary
Research Site 3607-0
🇭🇺Tatabanya, Hungary
Research Site 9702-0
🇮🇱Jerusalem, Israel
Research Site 9703-0
🇮🇱Kfar-Saba, Israel
Research Site 9704-0
🇮🇱Petach-Tikva, Israel
Research Site 9705-0
🇮🇱Rehovot, Israel
Research Site 3908-0
🇮🇹Bergamo, Italy
Research Site 3907-0
🇮🇹Brescia, Italy
Research Site 3901-0
🇮🇹Catania, Italy
Research Site 3903-0
🇮🇹Catanzaro, Italy
Research Site 3906-0
🇮🇹Milano, Italy
Research Site 3911-0
🇮🇹Milano, Italy
Research Site 3904-0
🇮🇹Milano, Italy
Research Site 3909-0
🇮🇹Napoli, Italy
Research Site 3905-0
🇮🇹Verona, Italy
Research Site 8211-0
🇰🇷Wonju, Gangwon-do, Korea, Republic of
Research Site 8204-0
🇰🇷Seongnam, Gyeonggi-do, Korea, Republic of
Research Site 8201-0
🇰🇷Seoul, Gyeonggi-do, Korea, Republic of
Research Site 8202-0
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of
Research Site 8208-0
🇰🇷Busan, Korea, Republic of
Research Site 8209-0
🇰🇷Incheon, Korea, Republic of
Research Site 8207-0
🇰🇷Seoul, Korea, Republic of
Research Site 8206-0
🇰🇷Seoul, Korea, Republic of
Research Site 8210-0
🇰🇷Seoul, Korea, Republic of
Research Site 8203-0
🇰🇷Seoul, Korea, Republic of
Research Site 8205-0
🇰🇷Seoul, Korea, Republic of
Research Site 4802-0
🇵🇱Rzeszów, Poland
Research Site 4807-0
🇵🇱Torun, Poland
Research Site 4803-0
🇵🇱Łódź, Poland
Research Site 3403-0
🇪🇸Sant Cugat del Valles, Barcelona, Spain
Research Site 3409-0
🇪🇸Santiago de Compostela, La Coruña, Spain
Research Site 3406-0
🇪🇸Majadahonda, Madrid, Spain
Research Site 3410-0
🇪🇸Barcelona, Spain
Research Site 3402-0
🇪🇸Barcelona, Spain
Research Site 3404-0
🇪🇸Barcelona, Spain
Research Site 3416-0
🇪🇸Madrid, Spain
Research Site 3407-0
🇪🇸Madrid, Spain
Research Site 3414-0
🇪🇸Madrid, Spain
Research Site 3401-0
🇪🇸Madrid, Spain
Research Site 3415-0
🇪🇸Málaga, Spain
Research Site 3408-0
🇪🇸Sevilla, Spain
Research Site 3413-0
🇪🇸Sevilla, Spain
Research Site 3412-0
🇪🇸Valencia, Spain
Research Site 4404-0
🇬🇧Truro, Cornwall, United Kingdom
Research Site 4408-0
🇬🇧London, Greater London, United Kingdom
Research Site 4409-0
🇬🇧London, Greater London, United Kingdom
Research Site 4402-0
🇬🇧Manchester, Greater Manchester, United Kingdom
Research Site 4407-0
🇬🇧Leeds, West Yorkshire, United Kingdom
Research Site 4401-0
🇬🇧Nottingham, United Kingdom
Research Site
🇨🇳Baoding, Hebei, China