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BioNTech

BioNTech logo
🇩🇪Germany
Ownership
Public
Employees
6.1K
Market Cap
$20.7B
Website
http://www.biontech.de
Introduction

BioNTech SE operates as immunotherapy company, which engages therapies for cancer and other serious diseases. Its product pipeline include BNT162b2, BNT161, BNT164, FixVac, iNeST, RiboMabs, CAR-T Cells, TCRs and Next-Gen CP Immunomodulators. The company was founded by Christopher Huber, Oezlem Tuereci, and Ugur Sahin on June 2, 2008 and is headquartered in Mainz, Germany.

Clinical Trials

107

Active:48
Completed:24

Trial Phases

5 Phases

Phase 1:71
Phase 2:21
Phase 3:7
+2 more phases

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (102 trials with phase data)• Click on a phase to view related trials

Phase 1
71 (69.6%)
Phase 2
21 (20.6%)
Phase 3
7 (6.9%)
Not Applicable
1 (1.0%)
phase_1_2
1 (1.0%)
Phase 4
1 (1.0%)

A Clinical Study Investigating the Therapeutic Effects and Safety of an Investigational Cell Therapy Given With and Without an Additional Investigational Product in Males With Testicular Cancer or a Form of Cancer That Developed From Sperm

Phase 2
Withdrawn
Conditions
Testicular Germ Cell Tumor
Extragonadal Germ Cell Tumor
Interventions
Biological: CLDN6 CAR-T
First Posted Date
2025-04-23
Last Posted Date
2025-07-02
Lead Sponsor
BioNTech SE
Target Recruit Count
150
Registration Number
NCT06940804

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Phase 1
Recruiting
Conditions
Advanced Lung Cancer
Interventions
First Posted Date
2025-03-24
Last Posted Date
2025-07-11
Lead Sponsor
BioNTech SE
Target Recruit Count
594
Registration Number
NCT06892548
Locations
🇺🇸

Precision NextGen Oncology and Research Center, Beverly Hills, California, United States

🇺🇸

Virginia Cancer Specialists, Fairfax, Virginia, United States

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy Following Chemoimmunotherapy

Phase 2
Recruiting
Conditions
Non-small Cell Lung Cancer
Interventions
First Posted Date
2025-02-24
Last Posted Date
2025-07-08
Lead Sponsor
BioNTech SE
Target Recruit Count
60
Registration Number
NCT06841055
Locations
🇺🇸

Baptist Health Hardin, Elizabethtown, Kentucky, United States

🇺🇸

NYU Langone - NYU Grossman School of Medicine, New York, New York, United States

🇺🇸

Millennium Research and Clinical Development, LLC, Houston, Texas, United States

and more 2 locations

A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

Phase 1
Recruiting
Conditions
Locally Advanced Breast Cancer
Unresectable Breast Carcinoma
Metastatic Breast Cancer
Interventions
First Posted Date
2025-02-14
Last Posted Date
2025-07-11
Lead Sponsor
BioNTech SE
Target Recruit Count
380
Registration Number
NCT06827236
Locations
🇨🇳

Huizhou First Hospital, Huizhou, China

🇨🇳

Fudan University Shanghai Cancer, Shanghai, China

🇺🇸

Hematology - Oncology Associates of the Treasure Coast, Port Saint Lucie, Florida, United States

and more 1 locations

A Study to Learn About How the Flu and COVID-19 Vaccines Act in Healthy People

Phase 1
Recruiting
Conditions
Influenza
COVID-19 (Coronavirus Disease 2019)
Interventions
Biological: Investigational COVID-19 Vaccine
Combination Product: Investigational Influenza and COVID-19 Combination Vaccine
Biological: Licensed COVID-19 Vaccine
Biological: Licensed Influenza Vaccine 3
Biological: Licensed Influenza Vaccine 1
Biological: Licensed Influenza Vaccine 2
Biological: Investigational Influenza Vaccine
First Posted Date
2025-02-11
Last Posted Date
2025-06-24
Lead Sponsor
BioNTech SE
Target Recruit Count
2645
Registration Number
NCT06821061
Locations
🇺🇸

Upstate Global Health Institute, East Syracuse, New York, United States

🇺🇸

University of Rochester Medical Center, Rochester, New York, United States

🇺🇸

AMR Clinical, Knoxville, Tennessee, United States

and more 26 locations
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News

Sartorius Stedim Biotech Partners with Sensible Biotechnologies to Scale Cell-Based mRNA Manufacturing Platform

Sartorius Stedim Biotech and Sensible Biotechnologies have signed a Memorandum of Understanding to advance the industrialization of Sensible's first-in-class cell-based mRNA manufacturing platform.

Everest Medicines Advances AI-Powered mRNA Platform with Cancer Vaccine Breakthroughs

Everest Medicines unveiled major breakthroughs in its proprietary AI-powered mRNA platform during its 2025 R&D Day, showcasing a fully integrated system spanning antigen design to manufacturing.

NCT/UCC Dresden Launches Phase 2 Trial of Personalized mRNA Vaccine for Pancreatic Cancer

NCT/UCC Dresden becomes the only site in Saxony to offer patients access to BioNTech and Genentech's personalized mRNA vaccine Autogene Cevumeran for pancreatic cancer treatment.

BioNTech Shuts Down Maryland Cell Therapy Manufacturing Following CAR-T Trial Failure

BioNTech will lay off 63 employees and wind down cell therapy manufacturing at its Gaithersburg, Maryland facility by the end of 2025 following disappointing Phase 1 trial results.

BioNTech to Acquire CureVac for $1.25 Billion to Strengthen mRNA Cancer Immunotherapy Pipeline

BioNTech announced a $1.25 billion all-stock acquisition of CureVac through a public exchange offer, offering $5.46 per CureVac share representing a 55% premium to strengthen its mRNA-based cancer immunotherapy capabilities.

RFK Jr. Replaces Entire CDC Vaccine Advisory Committee with Eight New Members

Health Secretary Robert F. Kennedy Jr. has replaced all 17 members of the CDC's Advisory Committee on Immunization Practices with eight new appointees, significantly downsizing the committee.

Bristol Myers Squibb Partners with BioNTech in $11.1 Billion Deal for Dual-Target Cancer Immunotherapy

Bristol Myers Squibb will pay BioNTech $1.5 billion upfront plus $2 billion in anniversary payments through 2028 for a 50% partnership in BNT327, a bispecific antibody targeting both PD-L1 and VEGF proteins.

FDA Expands Warning for mRNA COVID-19 Vaccines Due to Heart Side Effect Risk in Young Males

The FDA has ordered Pfizer and Moderna to expand warning labels on their COVID-19 vaccines regarding myocarditis and pericarditis risk, particularly in males aged 16-25, with an incidence rate of 38 cases per million doses.

Breakthrough in Targeted Drug Delivery: Novel Bacteriophage-Loaded Wound Dressings Show Promise for Chronic Infections

Professor Maike Windbergs and her team at Goethe University Frankfurt have developed innovative wound dressings using electrospinning technology that gradually release bacteriophages to combat resistant bacteria in chronic wounds.

Ethris and Lonza Partner to Develop Room-Temperature Stable mRNA Respiratory Vaccines

Ethris and Lonza have formed a strategic partnership to develop spray-dried mRNA vaccines for respiratory diseases that remain stable at room temperature, eliminating cold chain requirements.

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