Effect of Exercise Training on Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease and Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Chemoreflex control of MSNA at rest and during exercise.
研究概览
简要总结
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive sleep apnea (OSA) will potentiate these responses. And, that the exercise training would decrease the chemoreflex response of MSNA in these patients.
详细描述
Forty patients with coronary artery disease, with (n=20) and without (n=20) obstructive sleep apnea will be studied. A healthy control, age-paired group (n=10) will be also evaluated. The patients will be submitted to a polysomnography and randomized for clinical follow-up or exercise training for four months. It will evaluated the autonomic function, chemoreflex control of sympathetic activity during hypoxic and hypercapnic maneuvers, endothelial function and inflammatory markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of stable coronary artery disease; Age between 35-60 years, male and female; BMI <30 kg/m2 Not involved in a regular exercise program at least three months before the survey;
排除标准
- •Patients with angina and / or ischemia,
- •Patients with diabetic neuropathy and / or ischemia of the lower limbs;
- •Previous diagnosis of chronic pulmonary, neurological and orthopedic diseases, neoplasia, renal failure and insulin-dependent diabetes mellitus;
- •Patients with acute myocardial infarction, cardiac surgery or hospitalization of cardiac origin six months before the study and carriers of pacemaker / implantable defibrillator;
- •Patients with cardiac dysfunction (ejection fraction of left ventricle <40%);
- •Current smoking and pregnant women.
研究组 & 干预措施
Control Group
Healthy control group for comparisons with coronary artery disease groups.
CAD without OSA - Control
Clinical follow-up.
CAD without OSA - Intervention
Aerobic exercise training.
干预措施: Aerobic exercise training (Other)
CAD with OSA - Control
Clinical follow-up.
CAD with OSA - Intervention
Aerobic exercise training.
干预措施: Aerobic exercise training (Other)
结局指标
主要结局
Chemoreflex control of MSNA at rest and during exercise.
时间窗: baseline and after 4 months
Chemoreflex control of MSNA will be measured by microneurography technique during the gas mixture known exposure at rest and during exercise
次要结局
- Endothelial Function(baseline and after 4 months)
- Neurovascular Control(baseline and after 4 months)
- Inflammatory markers(baseline and after 4 months)
- Quality of Life(baseline and after 4 months)
- Mood State(baseline and after 4 months)
- Anxiety Trait and State(baseline and after 4 months)
- Symptoms of Depression(baseline and after 4 months)