Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 320
- 试验地点
- 1
- 主要终点
- Measurement of serum uric acid levels in all patients
研究概览
简要总结
The purpose of this study is to confirm the protective effect and mechanism of anthocyanins on hyperuricemia patients with Cardiovascular disease.
详细描述
Hyperuricemia patients who have the ability to complete the intervention study in the early stage of study were selected as the research subjects. A randomized controlled double blind control method was used to study the effect of one year of anthocyanins intervention. Serum UA levels, oxidative stress, AGEs, and endothelial function are detecting in patients with hyperuricemia who were treated with anthocyanins and placebo. Providing scientific basis of anthocyanins for the treatment with hyperuricemia and delaying atherosclerosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Serum uric acid >420μmol/L (7mg/dL) in male, >360μmol/L (6mg/dL) in female identified as hyperuricemia patients.
排除标准
- •Age more than 60 years and less than 30 years old;
- •acute infection, tumor, recent surgery, need for hemodialysis and autoimmune diseases.
研究组 & 干预措施
Placebo capsule
Simple hyperuricemia patients and with coronary heart disease in hospital. Double blind, randomized method. Control group taking placebo capsule
干预措施: Placebo capsule (Dietary Supplement)
Anthocyanidins capsule
Simple hyperuricemia patients and with coronary heart disease in hospital. Double blind, randomized method. The experimental group taking anthocyanins capsule.
干预措施: Anthocyanidins capsule (Dietary Supplement)
Allopurinol
The experimental group taking allopurinol.
干预措施: Allopurinol (Drug)
结局指标
主要结局
Measurement of serum uric acid levels in all patients
时间窗: up to 1 months
Serum uric acid (mg/dl) is determined by Uric Acid kit on an automated system.
次要结局
- Measurement of advanced glycation end products and its receptor level in all patients(up to 2 months)
研究者
Yuan Zhang
Doctor of Medicine
Guangzhou General Hospital of Guangzhou Military Command