Efficacy of Antibiotic Short Course for Bloodstream Infections in Acute Myeloid Leukemia Patients With Febrile Neutropenia: a Retrospective Comparative Study
Overview
- Phase
- Not Applicable
- Intervention
- Antibiotic
- Conditions
- Bloodstream Infection
- Sponsor
- Poitiers University Hospital
- Enrollment
- 104
- Locations
- 1
- Primary Endpoint
- Bloodstream infection relapses
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
There is no specific recommendation about antimicrobial treatment length for documented infections in chemotherapy induced febrile neutropenia. The aim of this study was to compare long versus short antibiotic course for bloodstream infection treatment in acute myeloid leukemia patients during febrile neutropenia. This monocentric retrospective comparative study included all consecutive bloodstream infection episodes among acute myeloid leukemia patients with febrile neutropenia for 3 years (2017-2019). Episodes were classified regarding the length of antibiotic treatment, considered as short course if the treatment lasted ≤7 days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was ≤10 days and ≤14 days, respectively. The primary outcome was the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute myeloid leukemia
- •chemo-induced febrile neutropenia
- •Bloodstream infection
Exclusion Criteria
- •lack of data
- •endovascular infections
- •surgical treatment required
- •central nervous system infections
- •antibiotic treatment \< 4 days
- •death before the end of antibiotic treatment
- •unappropriated antibiotic treatment at 48h
- •relapses of bloodstream infection episodes already included
- •hematopoietic stem cell transplant
Arms & Interventions
Short course treatment
Patients who received antibiotic for 7 or less days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was 10 days and 14 days, respectively.
Intervention: Antibiotic
Long course treatment
Patients who received antibiotic for more than 7 days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was 10 days and 14 days, respectively.
Intervention: Antibiotic
Outcomes
Primary Outcomes
Bloodstream infection relapses
Time Frame: within 30 days of antibiotic discontinuation
The primary outcome was to compare the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
Secondary Outcomes
- Mortality(within 30 days of antibiotic discontinuation)
- Epidemiology of bacteria(at baseline)
- Risk factors for relapses(within 30 days of antibiotic discontinuation)