Efficacy of Antibiotic Short Course for Bloodstream Infections in Acute Myeloid Leukemia Patients With Febrile Neutropenia: a Retrospective Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Bloodstream infection relapses
研究概览
简要总结
There is no specific recommendation about antimicrobial treatment length for documented infections in chemotherapy induced febrile neutropenia. The aim of this study was to compare long versus short antibiotic course for bloodstream infection treatment in acute myeloid leukemia patients during febrile neutropenia. This monocentric retrospective comparative study included all consecutive bloodstream infection episodes among acute myeloid leukemia patients with febrile neutropenia for 3 years (2017-2019). Episodes were classified regarding the length of antibiotic treatment, considered as short course if the treatment lasted ≤7 days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was ≤10 days and ≤14 days, respectively. The primary outcome was the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute myeloid leukemia
- •chemo-induced febrile neutropenia
- •Bloodstream infection
排除标准
- •lack of data
- •endovascular infections
- •surgical treatment required
- •central nervous system infections
- •antibiotic treatment < 4 days
- •death before the end of antibiotic treatment
- •unappropriated antibiotic treatment at 48h
- •relapses of bloodstream infection episodes already included
- •hematopoietic stem cell transplant
研究组 & 干预措施
Short course treatment
Patients who received antibiotic for 7 or less days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was 10 days and 14 days, respectively.
干预措施: Antibiotic (Drug)
Long course treatment
Patients who received antibiotic for more than 7 days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was 10 days and 14 days, respectively.
干预措施: Antibiotic (Drug)
结局指标
主要结局
Bloodstream infection relapses
时间窗: within 30 days of antibiotic discontinuation
The primary outcome was to compare the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
次要结局
- Mortality(within 30 days of antibiotic discontinuation)
- Epidemiology of bacteria(at baseline)
- Risk factors for relapses(within 30 days of antibiotic discontinuation)