Epidemiology of Bacteremia at Two Tertiary ICUs in Switzerland

Completed

• Conditions: Bacteremia
• Interventions: Diagnostic Test: Blood Culture

• Registration Number: NCT05236283
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

The objectives of the retrospective cohort study is to describe the actual current practice of antibiotic treatment duration for bloodstream infections in critically ill patients at two tertiary hospitals (ICU Inselspital Bern and ICU CHUV Lausanne), to examine patient, pathogen and infectious syndrome factors associated with selection of shortened treatment duration, and to describe the expected time course of clinical resolution among bacteremic patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-02-01
• Study First Submitted: 2022-02-01
• Study First Submitted QC: 2022-02-01
• Study First Posted: 2022-02-11
• Primary Completion: 2022-03-01
• Study Completion: 2022-03-30
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-25
• Last Update Posted: 2023-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 395

Inclusion Criteria

Patient has a positive blood culture with a pathogenic organism Patient is critically ill at the time the blood culture was collected as defined by the following:

1. was treated at the ICU/IMC at the time of blood culture collection;
2. or has been admitted to ICU/IMC in the 48 hours after blood culture collection

Exclusion Criteria

1. Patient has a single positive blood culture with a common contaminant organism:

   • coagulase negative staphylococci;
   • Bacillus spp.;
   • Corynebacterium spp.;
   • Propionibacterium spp.;
   • Aerococcus spp.;
   • Micrococcus spp.

2. Explicit documentation that the patient does not want to participate in any study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Bern ICU	Blood Culture	-
Lausanne ICU	Blood Culture	-

Primary Outcome Measures

Name	Time	Method
Antibiotic Treatment Duration	Hospital discharge, expected to be on average ca. 15-20 days	Days of adequate antibiotic treatment in Patients with Bacteremia

Secondary Outcome Measures

Name	Time	Method
Days of hospital stay	Hospital discharge, expected to be on average ca. 15-25 days	Days of Inhospital Stay in Patients with Bacteremia
Days of ICU stay	ICU discharge, expected to be on average ca. 5-15 days	Days of ICU Stay in Patients with Bacteremia

Trial Locations

Locations (1)

Departement of Intensive Care Medicine; 🇨🇭 Bern, Switzerland