Duration of Antimicrobial Treatment for Bloodstream Infections in Swiss Critically Ill Patients - Retrospective Double Center Study

Insel Gruppe AG, University Hospital Bern1 site in 1 country395 target enrollmentFebruary 1, 2022

ConditionsBacteremia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Bacteremia
Sponsor: Insel Gruppe AG, University Hospital Bern
Enrollment: 395
Locations: 1
Primary Endpoint: Antibiotic Treatment Duration
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The objectives of the retrospective cohort study is to describe the actual current practice of antibiotic treatment duration for bloodstream infections in critically ill patients at two tertiary hospitals (ICU Inselspital Bern and ICU CHUV Lausanne), to examine patient, pathogen and infectious syndrome factors associated with selection of shortened treatment duration, and to describe the expected time course of clinical resolution among bacteremic patients.

Registry

clinicaltrials.gov

Start Date

February 1, 2022

End Date

March 30, 2022

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Insel Gruppe AG, University Hospital Bern

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patient has a positive blood culture with a pathogenic organism Patient is critically ill at the time the blood culture was collected as defined by the following:
•was treated at the ICU/IMC at the time of blood culture collection;
•or has been admitted to ICU/IMC in the 48 hours after blood culture collection

Exclusion Criteria

•Patient has a single positive blood culture with a common contaminant organism:
•coagulase negative staphylococci;
•Bacillus spp.;
•Corynebacterium spp.;
•Propionibacterium spp.;
•Aerococcus spp.;
•Micrococcus spp.
•Explicit documentation that the patient does not want to participate in any study

Outcomes

Primary Outcomes

Antibiotic Treatment Duration

Time Frame: Hospital discharge, expected to be on average ca. 15-20 days

Days of adequate antibiotic treatment in Patients with Bacteremia

Secondary Outcomes

Days of hospital stay(Hospital discharge, expected to be on average ca. 15-25 days)
Days of ICU stay(ICU discharge, expected to be on average ca. 5-15 days)