Effects on Recovery of Postoperative Gastrointestinal Function With Multimodal Analgesia
- Conditions
- Gastrointestinal Recovery
- Interventions
- Drug: Placebo
- Registration Number
- NCT04314310
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
breast cancer surgery is associated with a high incidence of persistant postsurgical pain (PPSP). The aim of the study was to evluate the impact of intravenous Tenoxicam on acute and PPSP, analgesic requirements and gastrointestinal recovery in patients undergoing surgery for breast cancer.
- Detailed Description
thrity patients participated in this randomized, single-blined study. Before and at the postoperative day 1, the bowel function (orocecal transmit time) were measured. Before induction of general anesthesia, patients recieved a bolus of intravenous Tenoxicam or an equal volume of saline (control group). Pain score and opioid consumption were recorded in the postoperative period and then daily for 1 week.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Female
- Target Recruitment
- 30
- ASA I to II Breast cancer patients Mastectomy or wide local excision + axillary note dissection
- Preexisting malignancy Chronic infection Previous pain condition Diabetes Thyroid disorder Severe cardiac, renal or hepatic disease Previous breast surgery Psychiatric illness Neurological disease Contraindication for tenoxicam or morphine use
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo Placebo equal volume of normal saline Tenoxicam Tenoxicam nonsteroidal anti-inflammatory drug (NSAID)
- Primary Outcome Measures
Name Time Method morphine consumption until postoperative day7 morphine consumption after breast cancer surgery
- Secondary Outcome Measures
Name Time Method orocecal transmit time, preoperative and postoperative day 1 smal intestinal function