Calprotectin I Serum as a Diagnostic Marker
Completed
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Registration Number
- NCT03474484
- Lead Sponsor
- St. Olavs Hospital
- Brief Summary
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Patients diagnosed with pneumonia in addition to an AECOPD experience more severe clinical and laboratory disease manifestations, increase in-hospital morbidity and worse outcome. Clinicians have sought for new biomarkers that together with clinical assessments can improve the diagnostic accuracy of pneumonia in patients with AECOPD.The aim of the present study is to compare the accuracy of calprotectin with procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 113
Inclusion Criteria
- clinically confirmed acute exacerbation of chronic obstructive pulmonary disorder (AECOPD)
- COPD diagnosis previously confirmed by spirometry according to the GOLD criteria.
Exclusion Criteria
- known malignant disease
- bronchiectasis
- chronic bacterial colonisation of the airways
- treatment with an immunosuppressive drug or long-term treatment with antibiotics.
- not examined with a chest X-ray at admission
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Calprotectin concentration in serum Change in serum concentration from baseline to 48 hours ELISA-kit (MRP8/14 ELISA)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Thoracic and Occupational Medicine
🇳🇴Trondheim, Trøndelag, Norway