Research for the Effectiveness of Combined Dietary Education of Low Sodium and High Potassium Consumption
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- changes of 24-hour ambulatory systolic and diastolic blood pressure
研究概览
简要总结
Reduction in sodium consumption is important approach in public health care. In general population, reduction of sodium intake can reduce the future development of hypertension and cardiovascular event. Meanwhile, enhancement of potassium consumption is also important to reduce blood pressure and cardiovascular events. We hypothesized that combined education of low sodium and high potassium consumption is more effective in reducing blood pressure compared to dietary education of low sodium consumption only.
The present survey study was designed to test the effectiveness of combined education of low sodium and high potassium consumption in blood pressure reduction and improvement of other variables.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Prehypertension: with a systolic pressure from 120 to 139 mm Hg or a diastolic pressure from 80 to 89 mm Hg
- •Stage 1 hypertension: with a systolic pressure from 140 to 159 mm Hg or a diastolic pressure from 90 to 99 mm Hg
排除标准
- •Urinary tract disease
- •Secondary hypertension
- •Previous history of unstable angina, heart failure, myocardial infarction, coronary revascularization, cerebrovascular disease within 12 months
- •Ventricular tachycardia, atrial fibrillation and flutter
- •Hypertrophic cardiomyopathy
- •Known chronic kidney disease: serum creatinine = or > 2.0 mg/dL
- •Hypokalemia (<3.5 mmol/L) or hyperkalemia (>5.5 mmol/L)
- •Type 1 diabetes mellitus
- •Poorly controlled diabetes mellitus (HbA1C = or > 9%)
- •Unable to collect 24 hour urine sample
- •Severe liver disease
- •Night workers
- •Mental retardation
结局指标
主要结局
changes of 24-hour ambulatory systolic and diastolic blood pressure
时间窗: 3 months
Effectiveness of combined dietary education of low sodium and high potassium consumption on changes of 24-hour ambulatory systolic and diastolic blood pressure, compared to dietary education of low sodium consumption only.
次要结局
- changes of renin and aldosterone(3 months)
- changes of 24-hour urine sodium and potassium excretion(3 months)
研究者
Moo-Yong Rhee
Professor, MD, PhD
DongGuk University