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临床试验/NCT01438619
NCT01438619已完成不适用

Sodium Intake: Research for the Improvement in Measurement Methods and the Effect of Sodium Intake on Cardiovascular Health

DongGuk University1 个研究点 分布在 1 个国家目标入组 620 人开始时间: 2011年4月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
620
试验地点
1
主要终点
Sodium intake in a studied community

研究概览

简要总结

Epidemiological, clinical and animal-experimental evidence shows a direct relationship between dietary sodium intake, blood pressure and cardiovascular event. Diverse questionnaire and 24 hour urinary sodium measurement are used to estimate sodium intake. Complete reflection of eating and cooking habits to the dietary survey method is difficult. Furthermore, the differences of database between countries make it difficult to compare the amount of sodium intake between countries. It is also difficult to consider individual variation of cooking and eating habits. Due to limitations of dietary survey method, WHO recommended 24 hour urinary sodium measurement to estimated sodium intake in the population survey, and many countries are adopting. However, in Korea National Health and Nutrition Examination Survey, only dietary survey method has been used.

The present survey study was designed 1) to test the feasibility of 24 hour urinary sodium measurement for the estimation of sodium intake (including percentage of complete 24 hour urine sample collection) in the population based study; 2) to establish feasible method of 24 hour urinary sodium measurement; 3) to compare 24 hour urinary sodium measurement to the dietary survey method; and 4) to estimate the sodium intake by 24 hour urinary sodium measurement in Goyang city general population (aged 20-70 years).

详细描述

Measurements: should be performed for 2 days

  1. 24 hour urine Na, K and Creatinine, 24 hour urine amount

  2. Calculation of urine completeness index : Creatinine/(21 x Bwt)

  3. Definition of incomplete urine collection: complete index less than 0.7 and loss of urine more than one time or 100 mL

  4. 24 hour ambulatory blood pressure

  5. mobile-O-graph (IEM GmbH)

  6. measurement interval: 30 minutes

  7. Measurement of peripheral blood pressure : microlife WatchBP office

  8. Sitting position

  9. After 5 minutes resting

  10. Peripheral systolic BP (pSBP), Peripheral diastolic BP (pDBP),

  11. Central aortic blood pressure

研究设计

研究类型
Observational
观察模型
Ecologic Or Community
时间视角
Cross Sectional

入排标准

年龄范围
20 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • General population who are reside in Goyang city

排除标准

  • Urinary tract disease
  • Known chronic kidney disease
  • Unable to measure 24 hour ambulatory blood pressure measurement
  • Unable to collect 24 hour urine sample
  • Pregnancy
  • Alcoholics
  • Severe liver disease
  • Night workers
  • Mental retardation

结局指标

主要结局

Sodium intake in a studied community

时间窗: Cross-section

Sodium intake of a community population is measured by 24 hour urinary sodium excretion

次要结局

  • The association between 24 hour urinary sodium excretion and ambulatory blood pressure(Cross-sectional)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Moo-Yong Rhee

Professor

DongGuk University

研究点 (1)

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