Sodium Intake: Research for the Improvement in Measurement Methods and the Effect of Sodium Intake on Cardiovascular Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 620
- 试验地点
- 1
- 主要终点
- Sodium intake in a studied community
研究概览
简要总结
Epidemiological, clinical and animal-experimental evidence shows a direct relationship between dietary sodium intake, blood pressure and cardiovascular event. Diverse questionnaire and 24 hour urinary sodium measurement are used to estimate sodium intake. Complete reflection of eating and cooking habits to the dietary survey method is difficult. Furthermore, the differences of database between countries make it difficult to compare the amount of sodium intake between countries. It is also difficult to consider individual variation of cooking and eating habits. Due to limitations of dietary survey method, WHO recommended 24 hour urinary sodium measurement to estimated sodium intake in the population survey, and many countries are adopting. However, in Korea National Health and Nutrition Examination Survey, only dietary survey method has been used.
The present survey study was designed 1) to test the feasibility of 24 hour urinary sodium measurement for the estimation of sodium intake (including percentage of complete 24 hour urine sample collection) in the population based study; 2) to establish feasible method of 24 hour urinary sodium measurement; 3) to compare 24 hour urinary sodium measurement to the dietary survey method; and 4) to estimate the sodium intake by 24 hour urinary sodium measurement in Goyang city general population (aged 20-70 years).
详细描述
Measurements: should be performed for 2 days
-
24 hour urine Na, K and Creatinine, 24 hour urine amount
-
Calculation of urine completeness index : Creatinine/(21 x Bwt)
-
Definition of incomplete urine collection: complete index less than 0.7 and loss of urine more than one time or 100 mL
-
24 hour ambulatory blood pressure
-
mobile-O-graph (IEM GmbH)
-
measurement interval: 30 minutes
-
Measurement of peripheral blood pressure : microlife WatchBP office
-
Sitting position
-
After 5 minutes resting
-
Peripheral systolic BP (pSBP), Peripheral diastolic BP (pDBP),
-
Central aortic blood pressure
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •General population who are reside in Goyang city
排除标准
- •Urinary tract disease
- •Known chronic kidney disease
- •Unable to measure 24 hour ambulatory blood pressure measurement
- •Unable to collect 24 hour urine sample
- •Pregnancy
- •Alcoholics
- •Severe liver disease
- •Night workers
- •Mental retardation
结局指标
主要结局
Sodium intake in a studied community
时间窗: Cross-section
Sodium intake of a community population is measured by 24 hour urinary sodium excretion
次要结局
- The association between 24 hour urinary sodium excretion and ambulatory blood pressure(Cross-sectional)
研究者
Moo-Yong Rhee
Professor
DongGuk University
