CADASIL MRI on 7 Tesla 'a cortical exploration journey'

Completed

• Conditions: CADASIL; 10027664; 10007963

• Registration Number: NL-OMON32570
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

Confirmed NOTCH3 mutation
Age: 18 years or older
Mental competency

Exclusion Criteria

MRI contraindications

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Average thickness of the specific cortical layers, compared to those of the<br /><br>control subjects<br /><br>- Focal abnormalities in the specific cortical layers<br /><br>- Average wall thickness of the medial meningeal artery and the relation with<br /><br>patient age, compared to control subjects<br /><br>- Shape of SLLs and relation with blood vessels<br /><br>- Number of microbleeds and age distribution</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n/a</p><br>