Hippocampal subregions volumes at 7 Tesla MRI in patients with early Alzheimer's disease and older persons with normal cognitio
Completed
- Conditions
- Alzheimer's Diseasedementia10042258
- Registration Number
- NL-OMON37919
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
Patients:
- Age >= 60 years
- Diagnosis problable or possible AD, or a precursor (amnestic MCI)
- Clinical Dementia Rating Scale (CDR) 0.5 or 1
- Mini-Mental State Examination (MMSE) > 20;Persons with normal cognition:
- Age >= 60 years
- No clinical diagnosis of MCI or dementia, or other neurological conditions that affect cognition
- No previous medical evaluations for cognitive complaints
- Clinical Dementia Rating Scale (CDR) 0
Exclusion Criteria
Patients and older persons with normal cognition:
- Contra indications for MR imaging (see appendices A and B of research protocol)
- Not being able to understand Dutch language
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure is hippocampal subregion volumes at 7 Tesla MRI. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcome measure is cognitive functioning.</p><br>