The Effects of Bolus, Intermittent and Continuous Enteral Feeding on Blood Glucose and Feeding Intolerance in ICU Patients With Sepsis
Not Applicable
Not yet recruiting
- Conditions
- Enteral Feeding Intolerance
- Interventions
- Other: enteral feedingProcedure: blood glucose measurementsProcedure: Evaluation of feeding intolerance with gastric residue
- Registration Number
- NCT05812664
- Lead Sponsor
- Umraniye Education and Research Hospital
- Brief Summary
Comparison of the effects of bolus, intermittent and continuous enteral feeding techniques on plasma glucose level and enteral feeding intolerance in adult intensive care unit patients with sepsis.
- Detailed Description
in this prospective, controlled trial the main aim is to evaluate the effects of bolus, intermittent and continuous enteral feeding techniques on plasma glucose level in intensive care patients with sepsis diagnosis and to determine whether they are superior to each other in providing norma-glycemia. The secondary aim is to determine the effect of these 3 different enteral feeding techniques on enteral feeding intolerance.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 93
Inclusion Criteria
- Hospitalized in ICU for more than 3 days
- Ages between 18-70 years
- APACHI II is in the range of 8-25
- BMI in the range of 18.5-30
- Able to receive enteral nutrition from N/G
- Intubated on ventilator support
- No previous diagnosis of Diabetes Mellitus,
- Those who have not had Gastro intestinal System surgery in the last 6 months
- Patients not receiving inotropic support
- not receiving hemodiafiltration
- No history of allergy to the food used
- Patients with a focus of infection and/or culture-positive patients diagnosed with sepsis according to Q SOFA (cultures were taken from all patients)
Exclusion Criteria
- patient's death during the study
- Taking more than 40 mg of IV steroids daily
- Increased baseline APACHI II score
- Development of the patient's need for inotropes
- Elimination of inclusion criteria
- negative culture
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description bolus feeding group blood glucose measurements bolus feeding method;The amount of food to be given for 24 hours calculated for the patient was given as 4 equal amounts for 40 minutes at 4 different times. Starting with 150 cc, the target calorie was reached by increasing 100 cc according to the intolerance before the next feeding hour. intermittent feeding group Evaluation of feeding intolerance with gastric residue The formula was started as 40 cc/h continuous infusion. It was interrupted after 5 hours. 30 minutes after the break, PGD was measured and intolerance was checked, and if the residue was negative, it was increased by 40 cc. The amount was increased until reaching the amount of formula that should be given for 24 hours calculated for the patient. This cycle was repeated 3 times in 24 hours. At 24:00, it was stopped and feeding was interrupted between 24:00 and 06:00. bolus feeding group enteral feeding bolus feeding method;The amount of food to be given for 24 hours calculated for the patient was given as 4 equal amounts for 40 minutes at 4 different times. Starting with 150 cc, the target calorie was reached by increasing 100 cc according to the intolerance before the next feeding hour. intermittent feeding group enteral feeding The formula was started as 40 cc/h continuous infusion. It was interrupted after 5 hours. 30 minutes after the break, PGD was measured and intolerance was checked, and if the residue was negative, it was increased by 40 cc. The amount was increased until reaching the amount of formula that should be given for 24 hours calculated for the patient. This cycle was repeated 3 times in 24 hours. At 24:00, it was stopped and feeding was interrupted between 24:00 and 06:00. bolus feeding group Evaluation of feeding intolerance with gastric residue bolus feeding method;The amount of food to be given for 24 hours calculated for the patient was given as 4 equal amounts for 40 minutes at 4 different times. Starting with 150 cc, the target calorie was reached by increasing 100 cc according to the intolerance before the next feeding hour. intermittent feeding group blood glucose measurements The formula was started as 40 cc/h continuous infusion. It was interrupted after 5 hours. 30 minutes after the break, PGD was measured and intolerance was checked, and if the residue was negative, it was increased by 40 cc. The amount was increased until reaching the amount of formula that should be given for 24 hours calculated for the patient. This cycle was repeated 3 times in 24 hours. At 24:00, it was stopped and feeding was interrupted between 24:00 and 06:00. continous feeding group enteral feeding The same method was applied as in Group 2. However, after 24:00, feeding was not interrupted and continued as the 4th cycle. continous feeding group blood glucose measurements The same method was applied as in Group 2. However, after 24:00, feeding was not interrupted and continued as the 4th cycle. continous feeding group Evaluation of feeding intolerance with gastric residue The same method was applied as in Group 2. However, after 24:00, feeding was not interrupted and continued as the 4th cycle.
- Primary Outcome Measures
Name Time Method effect of enteral feeding methods on blood glucose levels for 7 days after the start of feeding Evaluation of hypo/hyperglycemia development by measuring blood glucose level 4 times a day
- Secondary Outcome Measures
Name Time Method feeding intolerance during the 7th day with the start of feeding effect on feeding intolerance, detection of more than half of the feeding amount will be taken as gastric residue positive so intolerance positive
Trial Locations
- Locations (1)
Umraniye Education and research hospital
🇹🇷Istanbul, Turkey