A comparison of bolus and continuous feeding with respect to vasopressor requirements in sepsis and septic shock patients.
Not Applicable
- Conditions
- Health Condition 1: A419- Sepsis, unspecified organism
- Registration Number
- CTRI/2021/07/034796
- Lead Sponsor
- FORTIS ESCORTS HEART INSTITUTE
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Adults > 18 years of age
2.Patients of sepsis and septic shock as per sepsis 3 definition
3.Admitted to ICU with Nasogastric, Orogastric or Nasojejunal tube for enteral feeding.
4.Patient informed and consented to be included in the study.
5.Patient will be enrolled in the study within 6 hours of start of enteral feeding.
Exclusion Criteria
1.Patient on parenteral nutrition
2.Active bowel obstruction as diagnosed clinically
3.Mesenteric ischemia
4.GI infection precluding Enteral Nutrition
5.Any other contraindications to Enteral nutrition
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.change in vasopressor dose over 1st 72 hours of EN <br/ ><br>2.Addition of any vasopressor drug in order to maintain MAP â?¥65mm of Hg. <br/ ><br>3.Serum lactate level as a marker of hypoperfusion <br/ ><br>Timepoint: every 12th hour until 72 hours
- Secondary Outcome Measures
Name Time Method Incidence of gastro intestinal tract complications <br/ ><br>1. Dairrhoea defined as having â?¥ 3 stools (loose/ liquid), with a stool weight 200 grams per day <br/ ><br>2.Vomiting <br/ ><br>3.Gastric residual volume , defined as aspirate volume 500 ml from feeding tube. <br/ ><br>4.Incidences of NOMI & NOBN <br/ ><br>5.ICU length of stay <br/ ><br>6.Discharged from hospital or Death. <br/ ><br>Timepoint: till 72 hours and then during discharge from ICU or hospital