ltrasound contrast agents to facilitate sonothrombolysis in patients with acute myocardial infarctio
Phase 2
Recruiting
- Conditions
- acute myocardial infarction1001108210003216
- Registration Number
- NL-OMON39042
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
* age 18-80 years
* acute onset (< 6 hours)
* sum ST elevation > 6mm + V3R > 1mm in case of an inferior infarction
* diagnosed with STEMI according to the criteria of the ACC (19)
* initial oral informed consent
Exclusion Criteria
* previous myocardial infarction
* clinical instability
* pregnancy / breast feeding
* known pulmonary hypertension (>90 mmHg)
* known allergy to ultrasound contrast agents
* any reason judged by the investigators to hamper inclusion
* Contraindications to alteplase
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* The effect of sonothrombolysis on the TIMI flow before primary PCI between<br /><br>the two patient groups.</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Cardiac function on follow-up, based on echocardiographic and MRI data.<br /><br>Enzymatic curves</p><br>