ltrasound contrast agents to facilitate sonothrombolysis in patients with acute myocardial infarctio

Not Applicable

Completed

• Conditions: Acute myocardial infarction; Circulatory System

• Registration Number: ISRCTN32486185
• Lead Sponsor: VU University Medical Centre (The Netherlands)

Brief Summary

2011 Protocol article in https://link.springer.com/article/10.1007/s12471-011-0100-x (added 20/08/2021) 2012 Results article in https://www.sciencedirect.com/science/article/abs/pii/S0301562911014785 (added 20/08/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-12-20
• Study Completion: 2006-12-01
• Last Update Posted: 30 August 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

1. Age 18 to 80 years
2. Diagnosed with acute myocardial infarction according to the criteria of the American College of Cardiology
3. Informed consent

Exclusion Criteria

1. Previous myocardial infarction
2. Clinical instability
3. Pregnancy/breast feeding
4. Known pulmonary hypertension
5. Known allergy to Optison
6. Any reason judged by the investigators to hamper inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Comparison of the UCA-group and the control group with respect to:<br> 1. Patency of the culprit coronary artery<br> 2. Thrombolysis In Myocardial Infarction (TIMI)-flow<br> 3. Corrected TIMI frame count<br> 4. Myocardial blush grade<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. ST-segment resolution<br> 2. Release of cardiac enzymes<br> 3. Echocardiographic wall motion score index<br> 4. Safety<br>