Cerebrovascular Dysregulation in Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Chronic Kidney Diseases

• Registration Number: NCT05571605
• Lead Sponsor: University of North Texas, Denton, TX

Brief Summary

The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).

Detailed Description

Prior research has shown that CKD patients have an increased risk of stroke and that impairments in brain blood flow regulation predict stroke in other chronic disease states. This study will test whether exercise training can improve brain blood flow regulation via improved dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in CKD. Participants will undergo exercise training on a stationary bicycle, or stretching exercises, 3 times per week for 12 weeks.

Study Timeline

• Study Start: 2022-08-01
• Study First Submitted: 2022-09-30
• Study First Submitted QC: 2022-10-04
• Study First Posted: 2022-10-07
• Primary Completion: 2025-02-28
• Study Completion: 2025-03-31
• Results First Submitted: 2025-06-11
• Status Verified: 2025-07
• Results First Submitted QC: 2025-07-01
• Last Update Submitted: 2025-07-01
• Results First Posted: 2025-07-20
• Last Update Posted: 2025-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Individuals with chronic kidney disease stages III-IV.

Exclusion Criteria

• Heart failure
• Chronic obstructive pulmonary disease
• Uncontrolled hypertension or hypotension
• Pregnancy or plans to become pregnant
• Inability to exercise on a stationary bicycle
• Current participation in exercise more than 20 minutes twice per week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Mean Arterial Pressure-Middle Cerebral Artery Blood Velocity Very Low Frequency Phase (Radians)	Mean arterial pressure-middle cerebral artery blood velocity transfer function phase (radians) will be compared at baseline (week 0) and after completing the 12-week intervention (week 13).	Mean arterial pressure was measured via finger photoplethysmography. Middle cerebral artery blood velocity was measured via transcranial Doppler ultrasound. A transfer function analysis was performed on the mean arterial pressure and middle cerebral artery blood velocity data to derive mean arterial pressure-middle cerebral artery blood velocity very low frequency phase (radians)
Mean Arterial Pressure-Middle Cerebral Artery Blood Velocity Very Low Frequency Gain (cm/s/mmHg)	Mean arterial pressure-middle cerebral artery blood velocity transfer function gain (cm/s/mmHg) will be compared at baseline (week 0) and after completing the 12-week intervention (week 13).	Mean arterial pressure was measured via finger photoplethysmography. Middle cerebral artery blood velocity data was measured via transcranial Doppler ultrasound. A transfer function analysis was performed on the mean arterial pressure and middle cerebral artery blood velocity data to derive mean arterial pressure-middle cerebral artery blood velocity gain (cm/s/mmHg).

Trial Locations

Locations (1)

University of North Texas; 🇺🇸 Denton, Texas, United States