Optimal Value Increase of Egg Products
- Conditions
- HealthyInflammationAging
- Registration Number
- NCT04606628
- Lead Sponsor
- University of Oslo
- Brief Summary
The aim of this project is to evaluate daily intake of eggshell membrane taken as supplement (capsule), will reduce markers of inflammation in older people.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 57
The study will include home-dwelling men and women ≥ 70 years. All subjects have to be in a good enough condition to meet up at the Department of Nutrition, University of Oslo at two occasions during the study period.
- CRP >10 mg/L
- Egg allergy
- Use of medication affecting inflammation
- Unstable use of medication or supplements last 3 months
- Unwilling to keep the physical activity level, habitual dietary intake, tobacco use and weight stable during the study period
- Severe illness last 3 months
- Unwilling to perform physical tests
- Eligibility
- Diabetes type I or II, HbA1c ≥ 6.5 %
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in plasma levels of inflammatory markers Measured at baseline and after 4 weeks (end of study) concentration of TNFalpha
- Secondary Outcome Measures
Name Time Method Peripheral blood mononuclear cell (PBMC) gene expression Measured at baseline and after 4 weeks mRNA levels of of genes involved in lipid metabolism and inflammation
Changes in metabolome plasma profile Measured at baseline and after 4 weeks concentration of low molecular molecules in blood
Changes in body weight Measured at baseline and after 4 weeks Weight (kg) measured by digital scale
Changes in body mass index (BMI) Measured at baseline and after 4 weeks Measured as body weight in kg/height in meter2 ( kg/m2)
Change in microbiota composition (optional) Measured at baseline and after 4 weeks bacteria type and diversity
Changes in physical performance Measured at baseline and after 4 weeks Short Physical Performance Battery (SPPB) test (includes balance test, chair test (sit to stand) and walk test)
Changes in body composition - measured by Bioimpedance (BIA) Measured at baseline and after 4 weeks fat free mass (% and kg), fatt mass (% and in kg)
Changes in markers related to lipid metabolism Measured at baseline and after 4 weeks Blood concentrations of e.g. triglycerides, total-, LDL- and HDL- cholesterol, free fatty acids and lipoprotein subclasses
Changes in satiety hormones Measured at baseline and after 4 weeks e.g. concentration of serum ghrelin, amylin, leptin
Change in muscle strength Measured at baseline and after 4 weeks Measured by grip strength
Trial Locations
- Locations (1)
University of Oslo
🇳🇴Oslo, Norway
University of Oslo🇳🇴Oslo, Norway