The role of androgens in sexual functioning of women with primary ovarian insufficiency: a comparative cross-sectional study

Completed

Conditions: premature menopause
seksuele functie- en fertiliteitsstoornissen
Premature ovarian failure (POF)
10033283
10014701

Registration Number: NL-OMON41190

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 174

Inclusion Criteria

- POI patient
- Being treated for POI
- Aged 18 - 39
- Understanding of Dutch language
- Able and willing to provide informed consent
- In a relationship (>3 months)
- Control groups should be using one of the following birth control methods: the second, third or fourth generation pill or Mirena intra uterine device

Exclusion Criteria

- Oophorectomy or radiation of the ovaries
- Androgen therapy during the six months prior to study start
- Lactation and/or pregnancy in the six months prior to study start
- Subjects experiencing relational discord as indicated by a score of >= 20 on the MMQ-M
- Other birth-control methods than described at inclusion criteria or no birth-control
- Chronic disease

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Hormone determinations:<br /><br>- FSH<br /><br>- 17-ß estradiol<br /><br>- total testosterone<br /><br>- SHBG<br /><br>- Free testosterone (calculated with Free Androgen Index (FAI): [total<br /><br>testosterone] / [SHBG] x 100)<br /><br>- DHEA<br /><br><br /><br>2. Genital response measured as VPA during:<br /><br>- self-induced erotic fantasy<br /><br>- watching sexual stimuli (erotic film)<br /><br>- at baseline<br /><br><br /><br>3. Subjective genital response determined by questions about:<br /><br>- overall feeling of sexual arousal<br /><br>- strongest feeling of sexual arousal<br /><br>- strongest genital sensation<br /><br>- amount of vaginal lubrication<br /><br><br /><br>4. Implicit associations respective to sexual stimuli by measuring reaction<br /><br>times</p><br>

Secondary Outcome Measures