Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (NAT-Geno)
- Conditions
- Prostate Cancer
- Registration Number
- NCT06960798
- Lead Sponsor
- University of Oklahoma
- Brief Summary
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prostate cancer. By examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.
- Detailed Description
This study aims to establish a comprehensive database of Native American (NA) patients diagnosed with prostate cancer (PC), focusing on an in-depth characterization of the genomic landscape. Archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. Whole exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohort. The study will initially enroll participants at the Stephenson Cancer Center, with planned expansion to additional sites across Oklahoma and, subsequently, to other institutions across the United States. Oversight will be maintained by the Tribal Institutional Review Board and an independent Community Advisory Board to ensure cultural appropriateness, transparency, and sustained community engagement throughout the research process. The overarching objective is to generate insights that will inform the development of personalized treatment strategies in the future.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Male
- Target Recruitment
- 150
- Written informed consent signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses.
- At least 18 years-of-age at the time of signature of the informed consent form (ICF).
- Patients who self-identify as Native American.
- Patients with a pathologically proven diagnosis of PC (any stage).
- Availability of most recent archived tumor samples.
- Patients not of Native American descent or identity.
- Patient does not have archival tissue available.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the genomic profiles of Prostate Cancer 1-3 years Comprehensively characterize the genomic profile of prostate cancer in Native American patients compared to Caucasian patients. Genetic testing will be conducted using Caris Whole Exome Sequencing (WES) and Whole Transcriptome Sequencing (WTS).
- Secondary Outcome Measures
Name Time Method Comparison of Genomic Profiles 1-3 years The study compares the Native American population with a reference Caucasian cohort to characterize molecular disparities and evaluate their clinical significance.
Trial Locations
- Locations (1)
OU Health Stephenson Cancer Center
🇺🇸Oklahoma City, Oklahoma, United States