Clinical, Physiological and Prognostic Implication of Microvascular Status
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT02186093
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
There are several physiologic parameters in evaluating cardiovascular disease. This study will reveal which parameter is the most proper value in predicting disease severity and risk factors of patients.
- Detailed Description
Fractional Flow Reserve (FFR), index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) will be measured in stable angina patients before coronary intervention.
Relationship between angiographic characteristics of patients and FFR, IMR, CFR will be analyzed. Comparison of risk factors and prognosis between parameters will be also analyzed. This study will evaluate that which parameter is correlate with disease severity and risk factors of patients.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1197
- Age ≥ 18
- Patients with stable angina
- FFR, IMR, CFR were measured before coronary intervention
- Patients who have severe side effects or contraindication to hyperemic agents (ex. adenosine)
- Patients with hemodynamic instability
- elevation of cardiac enzymes, evidence of acute MI, or a culprit vessel of acute coronary syndrome
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Spearman correlation coefficient between FFR, IMR, CFR and angiographic severity during coronary angiography
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (5)
Keimyung University Dongsan medical center
🇰🇷Daegu, Korea, Republic of
Inje University Ilsan Paik Hospital
🇰🇷Goyang, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Ulsan University Hospital, University of Ulsan College of Medicine
🇰🇷Ulsan, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of