ACTRN12618000306213
Completed
Phase 4
Investigating the impact of regular cardio selective beta blockers on recovery with beta agonists following methacholine bronchoconstriction challenge in Asthmatics
Waikato District Health Board, Respiratory Research Fund0 sites21 target enrollmentMarch 1, 2018
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Asthma
- Sponsor
- Waikato District Health Board, Respiratory Research Fund
- Enrollment
- 21
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Physician diagnosis of asthma
- •Airway hyper responsiveness. Demonstrated with post mannitol ( a 15 percent decrease in FEV1 at a cumulative mannitol dose PD15 \<635mg/ml)
- •Over 18 years of age
Exclusion Criteria
- •Pre spirometry FEV1 \< 60% predicted or \< 1\.5L
- •Dyspnoea at rest
- •Past history of hypotension (baseline BP \<100/60\)
- •ECG abnormalities that could interfere with the interpretation of the study:
- •HR\<60/min
- •Symptomatic hypotension
- •ECG findings of severe 1st degree, or 2nd \& 3rd degree heart block (defined as PR interval \> 0\.28s)
- •LBBB \& RBBB are NOT excluded.
- •Known adverse reaction to beta blockers or mannitol
- •On other drugs that commonly interact with beta blockers (amiodarone, verapramil, cimetidine, digoxin, phenytoin)
Outcomes
Primary Outcomes
Not specified
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