Maternal Micronutrient Supplementation to Reduce Low Birth Weight and Infant and Maternal Morbidity in Rural Nepal

Johns Hopkins Bloomberg School of Public Health0 sites5,000 target enrollmentJanuary 1999

ConditionsLow Birth Weight Infant Mortality Pregnancy Nutritional Status

DrugsNutritional supplements

Overview

Phase: Phase 3
Intervention: Not specified
Conditions: Low Birth Weight
Sponsor: Johns Hopkins Bloomberg School of Public Health
Enrollment: 5000
Primary Endpoint: Birth weight
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The purpose of this study was to determine the effects of providing supplements containing alternative combinations of micronutrients during pregnancy on birth weight and other infant and maternal health and nutritional outcomes in a rural area of Nepal.

Detailed Description

Maternal micronutrient deficiencies are common in the developing world and may influence intrauterine growth and fetal and neonatal health and survival. Currently, policies for antenatal supplementation beyond iron-folic acid are not in place in these settings. And yet, the efficacy of such supplementation strategies has not been well established. Specifically, it is not clear if multiple micronutrient combinations will enhance fetal growth and newborn health and survival compared to single or smaller combinations of micronutrients. Also, while birth weight may serve as a proxy measure of newborn health, infant morbidity and mortality needs direct examination. Comparisons: Pregnant women received daily folic acid, folic acid plus iron, folic acid plus iron plus zinc, or a multiple micronutrient supplement containing 11 other nutrients all with vitamin A compared to a control group that received only vitamin A.

Registry

clinicaltrials.gov

Start Date

January 1999

End Date

May 2001

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel