The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Time to Platelet Aggregation as Measured Using Collagen-epinephrine (EPI)
研究概览
简要总结
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood is drawn from our patients pre-bypass after obtaining the arterial line and administered back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of heparin with protamine. In our practice we noticed some variability in the impact of ANH on postoperative bleeding; with some patients appearing to show more hemostasis after separation from CPB than others. This is a prospective study to find out if there is an optimal time period that guarantees the largest amount of functioning platelets and what is the best practice for drawing and storing of ANH to guarantee the largest amount of functioning platelets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients undergoing cardiac surgery on CPB and are determined to be suitable for ANH by the cardiac team during the huddle process per our standard protocol.
排除标准
- •Patients who are undergoing cardiac surgery on CPB who are determined not to be suitable candidates for ANH by the cardiac team during the huddle process per our standard protocol.
结局指标
主要结局
Time to Platelet Aggregation as Measured Using Collagen-epinephrine (EPI)
时间窗: Just prior to re-transfusion, assessed up to 5 minutes
The membrane of the cartridges are coated with collagen and epinephrine (EPI) inducing a platelet plug to form which closes the aperture.
Time to Platelet Aggregation as Measured Using Collagen-Adenosine (ADP)
时间窗: Just prior to re-transfusion, assessed up to 5 minutes
The membrane of the cartridges are coated with collagen and adenosine diphosphate (ADP) inducing a platelet plug to form which closes the aperture.
次要结局
未报告次要终点
研究者
Aymen N Naguib
Director of Pediatric Cardiothoracic Anesthesia
Nationwide Children's Hospital