NCT02777957
Unknown
Not Applicable
Predictors and Survival in Pulmonary Hypertension Associated With Severe Lung Disease
Silesian Centre for Heart Diseases1 site in 1 country200 target enrollmentDecember 2008
ConditionsPulmonary Hypertension
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Hypertension
- Sponsor
- Silesian Centre for Heart Diseases
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Survival after the initial right heart catheterization (RHC) measurements
- Last Updated
- 5 years ago
Overview
Brief Summary
First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation. Second, to assess the prevalence of PH and to identify which hemodynamic, echocardiographic, pulmonary functional test, exercise capacity and biochemical parameters (especially NT-proBNP) have an impact on survival in a cohort of patients with severe lung diseases referred for lung transplantation.
Investigators
Jolanta Nowak
MD, PhD
Silesian Centre for Heart Diseases
Eligibility Criteria
Inclusion Criteria
- •advanced lung disease
- •qualification for lung transplantation
- •written informed consent
- •pulmonary capillary wedge pressure \< 15 mmHg
Exclusion Criteria
- •history of idiopathic pulmonary hypertension,
- •primary valvular heart diseases,
- •coronary artery disease,
- •collagen vascular disease,
- •history or evidence of left ventricular dysfunction,
- •atrial fibrillation,
- •increased liver enzyme levels ( 3 times the upper laboratory limit),
- •renal dysfunction (estimated glomerular filtration rate \< 60 ml/min/1.73m2)
- •patients who didn't write the personal informed consent
- •any specific therapy for PH.
Outcomes
Primary Outcomes
Survival after the initial right heart catheterization (RHC) measurements
Time Frame: 1 year
Secondary Outcomes
- Survival to lung transplantation or the end of the observation period after the initial right heart catheterization (RHC) measurement(3 years)
Study Sites (1)
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