NCT02777957Unknown不适用
Predictors and Survival in Pulmonary Hypertension Associated With Severe Lung Disease
Silesian Centre for Heart Diseases1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2008年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Survival after the initial right heart catheterization (RHC) measurements
研究概览
简要总结
First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation. Second, to assess the prevalence of PH and to identify which hemodynamic, echocardiographic, pulmonary functional test, exercise capacity and biochemical parameters (especially NT-proBNP) have an impact on survival in a cohort of patients with severe lung diseases referred for lung transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •advanced lung disease
- •qualification for lung transplantation
- •written informed consent
- •pulmonary capillary wedge pressure < 15 mmHg
排除标准
- •history of idiopathic pulmonary hypertension,
- •primary valvular heart diseases,
- •coronary artery disease,
- •collagen vascular disease,
- •history or evidence of left ventricular dysfunction,
- •atrial fibrillation,
- •increased liver enzyme levels ( 3 times the upper laboratory limit),
- •renal dysfunction (estimated glomerular filtration rate < 60 ml/min/1.73m2)
- •patients who didn't write the personal informed consent
- •any specific therapy for PH.
结局指标
主要结局
Survival after the initial right heart catheterization (RHC) measurements
时间窗: 1 year
次要结局
- Survival to lung transplantation or the end of the observation period after the initial right heart catheterization (RHC) measurement(3 years)
研究者
Jolanta Nowak
MD, PhD
Silesian Centre for Heart Diseases
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue DiseasesConnective Tissue DiseasePulmonary HypertensionNCT01387035Heidelberg University50
Unknown
不适用
Persistent Pulmonary Hypertension After Percutaneous Mitral CommissurotomyPulmonary HypertensionNCT04083729Assiut University62
已完成
不适用
Study Performed at Various Medical Centers to Learn More About Survival and Expected Course of Pulmonary Arterial Hypertension, a Type of High Blood Pressure in the Lungs Related to the Narrowing of the Small Blood Vessels in the LungsPulmonary Arterial HypertensionNCT03863990Bayer104
已完成
不适用
Observatory: Search for Prognostic Factors of Pulmonary Hypertension Post-capillary in Heart FailurePost-capillary Pulmonary HypertensionHeart FailureNCT01545180French Cardiology Society665
已完成
不适用
Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed TomographyPulmonary Arterial HypertensionNCT01607489Medical University of Graz25