Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Connective Tissue Disease
- Sponsor
- Heidelberg University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Evaluation of various screening methods for their ability to predict and to confirm PH in scleroderma patients
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The purposes of this study are (I), to evaluate various screening methods for their ability to predict and to confirm Pulmonary Hypertension (PH) in scleroderma patients, and (II) to evaluate the incidence of PH (i.e. the number of new cases per year) in scleroderma patients.
Investigators
Prof. Dr. med. Ekkehard Gruenig
Prof. Dr. med. Ekkehard Grünig
Heidelberg University
Eligibility Criteria
Inclusion Criteria
- •consent form
- •men and women\> 18 years
- •fulfill the current definition of a collagen vascular disease according to the actual guidelines of the American College of Rheumatology (ACR)
Exclusion Criteria
- •all contraindications for exercise testing
- •significant restriction of the left ventricle, unstable coronary artery disease and myocardial infarction in the last 6 months
- •patients with other lung diseases (as the pulmonary infestations as part of systemic disease) or related musculoskeletal disorders influencing baseline exercise capacity
- •pregnancy
Outcomes
Primary Outcomes
Evaluation of various screening methods for their ability to predict and to confirm PH in scleroderma patients
Time Frame: 3 years
Correlate Spiroergometric, lung functional Magnetic Resonance Imaging (MRI) and echocardiographic parameters with invasive hemodynamic findings collected by right heart catheterization: which other non-invasive parameters can be found to detect pulmonary hypertension? Can pulmonary hypertension be detected at rest in the echocardiography? In which patients can only stress-Doppler echocardiography confirm manifest or latent pulmonary hypertension? Is stress-Doppler echocardiography a suitable for early detection of pulmonary hypertension in patients with collagen vascular disease?
Secondary Outcomes
- Subdivision of patients with connective tissue disease in different degrees of severity(3 years)