Human Ovarian Autotransplantation Using Cryopreserved Ovarian Tissue in Women Treated for Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Comparision of orthotopic and heterotopic autotransplantation
研究概览
简要总结
Chemotherapy can cause permanent damage to a woman's ovaries. Women who are cancer survivors may find that they are not able to produce female hormones, and they may not be able to have a child. Scientists are trying to find ways to help cancer survivors regain their hormonal function and possibly get pregnant, if they desire. Scientists have developed a method where ovarian tissue is removed and frozen before chemotherapy; then it is thawed and put back into the woman's body after she is cancer-free. Putting a woman's previously-frozen tissue back into her body is called ovarian autotransplantation.
Ovarian autotransplantation is a very new technique, and there have only been a small number of women who have had this procedure. So far, only five babies in the world have been born using this technique.
The purpose of this study is to learn more about ovarian autotransplantation. Scientists hope to find better ways to use this method to help a woman's ovaries start working again after chemotherapy. If the ovaries start working again, it might be possible to have a baby.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Adult women (age between 18 and 40) who stored the ovary before cancer therapy.
- •Adult women who completed cancer therapy and are in remission.
- •Adult women who desire to conceive and are ready to have a baby.
排除标准
- •Age under 18 or over 40 years old
- •Women with a disease at high risk for ovarian metastasis (such as leukemia)
- •Women with contraindication for surgery
- •Women with contraindication for pregnancy
- •Psychological instability to sustain pregnancy (diagnosed by a psychiatrist)
- •Women who are HIV Positive
研究组 & 干预措施
Ovarian autotransplantation
干预措施: Ovarian autotransplantation (Procedure)
结局指标
主要结局
Comparision of orthotopic and heterotopic autotransplantation
时间窗: 2009-2015
The main purpose of this study is to investigate restoration of ovarian function and fertility by autotransplantation of human ovarian tissue using heterotopic and orthotopic techniques
次要结局
未报告次要终点
研究者
Samuel Kim, MD
Associate Professor
University of Kansas Medical Center