Ovarian Tissue Cryopreservation and Subsequent Auto-Transplantation for Female Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Surgical complications
研究概览
简要总结
Ovarian Tissue Cryopreservation will be provided to cancer patients to allow them to have their fertility preserved.
详细描述
This project hopes to provide Ovarian Tissue Cryopreservation to patients who do not have adequate time for ovarian stimulation in oocyte or embryo freezing and in prepubertal girls where oocyte freezing is not possible. All the patients will have fertility preservation consultations with a fertility specialist in our unit to go through the details of ovarian Tissue Cryopreservation service and risks related to ovarian tissue cryopreservation procedures. After undergoing ovarian tissue collection via surgery, the collected ovarian tissue will be cryopreserved either by slow freezing or vitrification in our unit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 35 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients aged from 0-35 years old and diagnosed with cancer e.g., leukaemia, myeloproliferative or myelodysplastic diseases, lymphoma, bone tumours, neurological neoplasms and sarcoma, Paediatric bone marrow transplant patients
- •Patients with any illness or who will undergo any type of treatment that may cause irreversible damage to their fertility, such as extensive abdominal surgery, high toxicity medication and treatments;
- •Patients suffering from hormone-sensitive malignancies who will undergo medical treatment, such as radiotherapy and chemotherapy that is liable to damage their ovaries and deter them from conception in the future.
排除标准
- •Patients with no anticipated oncologic therapies
- •Patients who are pregnant
- •Children with one ovary
- •Children deemed high risk for perioperative complications
- •Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)
研究组 & 干预措施
Ovarian tissue freezing and subsequent auto-transplantation after thawing
Ovarian tissue freezing and subsequent auto-transplantation after thawing
干预措施: Ovarian tissue freezing and subsequent auto-transplantation after thawing (Procedure)
结局指标
主要结局
Surgical complications
时间窗: 15 years
Surgical complications after ovarian tissue transplantation
次要结局
- Pregnancy rate(15 years)
研究者
Chung Pui Wah Jacqueline
Associate Professor
Chinese University of Hong Kong