Machine Learning Assisted Differentiation of Low Acuity Patients at Dispatch

Not Applicable

Completed

• Conditions: Emergencies
• Interventions: Diagnostic Test: openTriage - Alitis algorithm

• Registration Number: NCT04757194
• Lead Sponsor: Uppsala University Hospital

Brief Summary

BACKGROUND:

At Emergency Medical Dispatch (EMD) centers, Resource Constrained Situations (RCS) where there are more callers requiring an ambulance than there are available ambulances are common. At the EMD centers in Uppsala and Västmanland, patients experiencing these situations are typically assigned a low-priority response, are often elderly, and have non-specific symptoms. Machine learning techniques offer a promising but largely untested approach to assessing risks among these patients.

OBJECTIVES:

To establish whether the provision of machine learning-based risk scores improves the ability of dispatchers to identify patients at high risk for deterioration in RCS.

DESIGN:

Multi-centre, parallel-grouped, randomized, analyst-blinded trial.

POPULATION:

Adult patients contacting the national emergency line (112), assessed by a dispatch nurse in Uppsala or Västmanland as requiring a low-priority ambulance response, and experiencing an RCS.

OUTCOMES:

Primary:

1. Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS) score

Secondary:

* Difference in composite risk score consisting of ambulance interventions, emergent transport, hospital admission, intensive care, and mortality between patients receiving immediate vs. delayed ambulance response during RCS.

* Difference in NEWS between patients receiving immediate vs. delayed ambulance response during RCS.

INTERVENTION:

A machine learning model will estimate the risk associated with each patient involved in the RCS, and propose a patient to receive the available ambulance. In the intervention arm only, the assessment will be displayed in a user interface integrated into the dispatching system.

TRIAL SIZE:

1500 RCS each consisting of multiple patients randomized 1:1 to control and intervention arms

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-01
• Study First Submitted: 2021-02-03
• Study First Submitted QC: 2021-02-11
• Study First Posted: 2021-02-17
• Primary Completion: 2024-11-30
• Study Completion: 2024-11-30
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-07
• Last Update Posted: 2025-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2499

Inclusion Criteria

• Identification of a resource constrained situation by ambulance director (i.e., 2 or more patients awaiting an ambulance response)
• Assigned priority 2A or 2B (Low-priority ambulance response) by dispatch nurse call-taker
• Valid Swedish personal identification number collected at dispatch
• Age >= 18 years

Exclusion Criteria

• Relevant calls received more than 30 minutes apart
• Logistical factors (eg. the patients' geographical locations) affect the ambulance assignment decision
• On scene risk factors (eg. a patient is outdoors and risks hypothermia) or risk mitigators (eg. healthcare staff already on-scene with a patient) affect the ambulance assignment decision

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	openTriage - Alitis algorithm	Calculation of risk assessment score by machine learning algorithm and display of risk assessment information to dispatch nurses. Staff encouraged but not required to comply with suggested ranking.

Primary Outcome Measures

Name	Time	Method
Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS).	Upon ambulance response (Within 8 hours of dispatch)	NEWS is a widely used and well-validated scoring algorithm based on objective patient vital signs, which are not causally dependent on the outcomes used to train the machine learning models investigated in this study. NEWS values will be based on the first set of vital signs obtained by ambulance nurses upon making contact with the patient. NEWS is measured on a 0-21 scale, with higher values corresponding to patients at higher risk for deterioration.

Secondary Outcome Measures

Name	Time	Method
Difference in National Early Warning Score (NEWS) between patients with immediate vs. delayed response.	Upon ambulance response (Within 8 hours of dispatch)	Per primary outcome
Difference in composite outcome measure score between patients with immediate vs. delayed response.	Up to 30 days	This measure investigates a composite score consisting of the outcomes used to train the machine learning models. The composite score is generated by identifying the following patient outcomes and assigning the corresponding weights: Abnormal intitial Arway/Breathing/Circulation findings by ambulance crew (4) Emergent (lights and sirens) transport to the hospital (2) Provision of prehospital interventions (1) Admission to in-patient care or mortality within 30 days (1); This results in a score from 0-8, with higher scores representing more

Trial Locations

Locations (2)

Västmanland hospital Västerås; 🇸🇪 Västerås, Västmanland, Sweden

Uppsala University Hospital; 🇸🇪 Uppsala, Sweden