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临床试验/NCT04757194
NCT04757194已完成不适用

Machine Learning Assisted Differentiation of Low Acuity Patients at Dispatch: A Randomized Controlled Trial

Uppsala University Hospital2 个研究点 分布在 1 个国家目标入组 2,499 人开始时间: 2021年2月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
2,499
试验地点
2
主要终点
Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS).

研究概览

简要总结

BACKGROUND:

At Emergency Medical Dispatch (EMD) centers, Resource Constrained Situations (RCS) where there are more callers requiring an ambulance than there are available ambulances are common. At the EMD centers in Uppsala and Västmanland, patients experiencing these situations are typically assigned a low-priority response, are often elderly, and have non-specific symptoms. Machine learning techniques offer a promising but largely untested approach to assessing risks among these patients.

OBJECTIVES:

To establish whether the provision of machine learning-based risk scores improves the ability of dispatchers to identify patients at high risk for deterioration in RCS.

DESIGN:

Multi-centre, parallel-grouped, randomized, analyst-blinded trial.

POPULATION:

Adult patients contacting the national emergency line (112), assessed by a dispatch nurse in Uppsala or Västmanland as requiring a low-priority ambulance response, and experiencing an RCS.

OUTCOMES:

Primary:

  1. Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS) score

Secondary:

  • Difference in composite risk score consisting of ambulance interventions, emergent transport, hospital admission, intensive care, and mortality between patients receiving immediate vs. delayed ambulance response during RCS.
  • Difference in NEWS between patients receiving immediate vs. delayed ambulance response during RCS.

INTERVENTION:

A machine learning model will estimate the risk associated with each patient involved in the RCS, and propose a patient to receive the available ambulance. In the intervention arm only, the assessment will be displayed in a user interface integrated into the dispatching system.

TRIAL SIZE:

1500 RCS each consisting of multiple patients randomized 1:1 to control and intervention arms

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Health Services Research
盲法
Single (Investigator)

盲法说明

Analyst masked to treatment group allocation in final analysis. Outcomes extracted algorithmically from databases.

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Identification of a resource constrained situation by ambulance director (i.e., 2 or more patients awaiting an ambulance response)
  • Assigned priority 2A or 2B (Low-priority ambulance response) by dispatch nurse call-taker
  • Valid Swedish personal identification number collected at dispatch
  • Age >= 18 years

排除标准

  • Relevant calls received more than 30 minutes apart
  • Logistical factors (eg. the patients' geographical locations) affect the ambulance assignment decision
  • On scene risk factors (eg. a patient is outdoors and risks hypothermia) or risk mitigators (eg. healthcare staff already on-scene with a patient) affect the ambulance assignment decision

结局指标

主要结局

Proportion of RCS where the first available ambulance was dispatched to the patient with the highest National Early Warning Score (NEWS).

时间窗: Upon ambulance response (Within 8 hours of dispatch)

NEWS is a widely used and well-validated scoring algorithm based on objective patient vital signs, which are not causally dependent on the outcomes used to train the machine learning models investigated in this study. NEWS values will be based on the first set of vital signs obtained by ambulance nurses upon making contact with the patient. NEWS is measured on a 0-21 scale, with higher values corresponding to patients at higher risk for deterioration.

次要结局

  • Difference in National Early Warning Score (NEWS) between patients with immediate vs. delayed response.(Upon ambulance response (Within 8 hours of dispatch))
  • Difference in composite outcome measure score between patients with immediate vs. delayed response.(Up to 30 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Hans Blomberg

Medical Director

Uppsala University Hospital

研究点 (2)

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