Brain development between ages 8 and 25: Intentional inhibition & reward-based learning

Recruiting

Conditions: GEEN AANDOENING! gezonde hersontwikkeling: hersenfunctie, hersenstructuur en gedrag
n.a.

Registration Number: NL-OMON34028

Lead Sponsor: niversiteit Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 220

Inclusion Criteria

See also page 17 in the protocol
1. Healthy children, adolescents and young adults without a history of neurological disorders
2. Right-handed
3. No counter-indications for MRI
4. Native Dutch speakers

Exclusion Criteria

1. Lefthanded
2. A history of psychiatric and/or neurological disorders
3. Counter-indications for MRI (such as metal implants, heart arrhythmia, claustrophobia, and possible pregnancy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective of these studies is to understand how the developmental<br /><br>changes in different regions of the brain are important for cognitive and<br /><br>emotional decision-making at different stages of development. To this end, we<br /><br>will acquire fMRI, sMRI and DTI data and behavioral responses of participants<br /><br>aged 8-25 years. Furthermore, these studies will be complemented with heart<br /><br>rate and skin conductance measures and with performance outside of the scanner<br /><br>on a battery of tests.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The goals of the current set of studies are to use functional Magnetic<br /><br>Resonance Imaging (fMRI) to:<br /><br>1. Identify brain regions that are associated with developmental changes in<br /><br>functions that may contribute to developmental changes in cognitive and<br /><br>emotional decision-making using three cross-sectional studies<br /><br>2. Identify the relationship between striatal responsiveness and prefrontal<br /><br>regulatory processing</p><br>