Anatomical-Clinical Base of Adenocarcinoma Pancreatic

Recruiting

• Conditions: Neoplasms; Adenocarcinoma; Carcinoma

• Registration Number: NCT06128343
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

BACAP-2 is a prospective biobank dedicated to the pancreatic adenocarcinoma including clinical data and biological samples from tumor. The aim is to enrich the previous propective collection BACAP in order to support future research projects.

Detailed Description

Pancreatic cancer represents the fourth cause of death by cancer in Western countries. In over 90% of cases, it is due to an adenocarcinoma. The only curative treatment for pancreatic cancer remains the surgical exeresis. This one can only be suggested as a curative treatment in only 10 to 15% of cases. Besides, prevention or screening is difficult to set up due to the absence of clearly identified risk factors or groups and to the absence of useful markers for the diagnosis in clinical practice.

The research efforts in this area must face a double challenge: saving time while improving the diagnosis period and strengthen the therapeutic equipment. It is important to identify and characterise the new molecular markers applicable for a better diagnosis and/or treatment (especially the response factors to chemotherapy).

The present project aims to enrich with fresh tumor tissue and somatic genetic analysis the existing propective collection BACAP in order to support support future research projects on:

* the development of new diagnostic tools,

* understanding the development of tumors of the pancreas

* the development of new therapeutic targets

* understanding the response to chemotherapy...

Study Timeline

• Study First Submitted: 2023-11-07
• Study First Submitted QC: 2023-11-07
• Study First Posted: 2023-11-13
• Study Start: 2023-11-16
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-29
• Last Update Posted: 2025-02-03
• Primary Completion: 2035-01-31
• Study Completion: 2035-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Patient with pancreatic mass syndrome explored by ultrasound endoscopy with cytopuncture or
• Patient with pancreatic mass syndrome explored by an abdominal scanner with and without injection of product contrast and/or puncture of the mass or secondary lesions by radiological route or
• Patient with pancreatic adenocarcinoma proven histologically and/or cytologically

Exclusion Criteria

• Patient with a pancreatic tumor whose analysis histological is not an adenocarcinoma
• Pregnant or breastfeeding patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Enrichment of prospective BACAP collection	5 years	This collection is coming to enrich the prospective BACAP collection of fresh tumor tissue and/or fixed from the micro-biopsy under endoscopic ultrasound

Trial Locations

Locations (8)

Haut-Lévêque Hospital; 🇫🇷 Bordeaux, France

Béthune hospital center; 🇫🇷 Béthune, France

Huriez Hospital; 🇫🇷 Lille, France

Jean Mermoz private hosptila; 🇫🇷 Lyon, France

Saint Eloi Hospital; 🇫🇷 Montpellier, France

Regional Cancer Center From Montpellier; 🇫🇷 Montpellier, France

PAU hospital; 🇫🇷 Pau, France

Rangueil hospital; 🇫🇷 Toulouse, France