Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis

Not Applicable

Completed

• Conditions: Postoperative Pulmonary Atelectasis; Negative Pressure Therapy
• Interventions: Other: novel recruitment maneuver therapy

• Registration Number: NCT06049173
• Lead Sponsor: Jilai Xiao

Brief Summary

1. Oxygenation index and bedside ultrasound would be used to evaluate the therapeutic effect of novel recruitment maneuver therapy in the patients with pulmonary atelectasis after cardiac surgery.

2. To establish a new therapy strategy for pulmonary atelectasis after cardiac surgery and to evaluate its effectiveness and safety for the cardiac patients complicated with postoperative pulmonary atelectasis.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-09-10
• Study First Submitted: 2023-09-10
• Study First Submitted QC: 2023-09-19
• Study First Posted: 2023-09-22
• Primary Completion: 2024-04-20
• Study Completion: 2024-04-20
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-01
• Last Update Posted: 2024-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• Age ≥ 18 years
• Underwent cardiac surgery with CPB
• Patients with lung ultrasound evidence of atelectasis after surgery
• Agree to participate in this study by themselves or their family member.

Exclusion Criteria

• Vasoactive-inotropic score (VIS)>20
• Patients who were not suitable for using abdominal CPR compression-decompression instrument: bleeding from abdominal organs, abdominal aortic aneurysm, large abdominal tumor, intra-abdominal hypertension, etc
• Hemothorax or large pleural effusion confirmed by ultrasonography/X-ray
• Pneumothorax or air leak confirmed by ultrasonography/X-ray
• Considered by other researchers to be unsuitable for participation in this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
novel recruitment maneuver therapy	novel recruitment maneuver therapy	The use of abdominal compression cardiopulmonary resuscitation apparatus for new recruitment maneuver therapy: the use of autonomous ventilation mode (PSV or CPAP) during mechanical ventilation, followed by abdominal compression recruitment maneuver therapy, the number of times of each compression is 5-10, each time the duration of 30 to 40s, and then adjust to the previous breathing pattern.

Primary Outcome Measures

Name	Time	Method
Lung ultrasound score (LUSS)	5 min before treatment and 5 min after treatment	The thorax was divided by the anterior axillary line, the posterior axillary line, and a horizontal line beneath the nipple. The intercostal spaces of each of the 12 areas were scanned and analyzed . Aeration loss was assessed by calculating the modified lung ultrasound score (LUSS), which showed sufficient sensitivity to detect aeration loss. Two lung ultrasound examiners provided scores for each area after simultaneous examination of the lung scan. LUSS was then calculated globally (LUSStot， as the sum of the 12 regions score, ranging from 0 to 36), and regionally (LUSSp, posterior, LUSSa, anterior and LUSSl, lateral regions).

Trial Locations

Locations (1)

Nanjing First Hospital; 🇨🇳 Nanjing, Nanjing, China