Excimer Light(308) Therapy for Resistant Alopecia Areata
- Conditions
- Alopecia Areata
- Registration Number
- NCT06149936
- Lead Sponsor
- Assiut University
- Brief Summary
This study aimed to evaluate the efficacy and safety of the 308-nm excimer lamp in resistant AA treated with topical minoxidil .
- Detailed Description
Alopecia areata (AA) is a chronic, nonscarring, T-cell mediated autoimmune disease, presenting with localized or diffuse hair fall in hair-bearing areas. Approximately 1.7% of the population experience an episode of AA during their lifetime. Both sexes are equally affected, and most new cases are recorded below the age of 30 years . Excimer laser using high-dose monochromatic UV radiation can trigger apoptosis and induce immunological suppression through altering cytokine production such as IL-4, IL-10, prostaglandin E2, platelet-activating factor, and cis-urocanic acid. Benefits have only been seen with localized patches of AA, and regrowth of hair occurs only in treated areas .
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 20
-
● Having multiple patches of AA.
- Duration of alopecia >1 year
- No topical or systemic treatment for the last 4 months
- Agreement to regular visits for treatment and follow-up.
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● A single form of AA.
- Alopecia for <1 year.
- Being on other modalities of treatment.
- Treatment within the last 4 months.
- Photosensitive disorders.
- Pregnancy or breastfeeding.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method alopecia areata with ecimer light 3 months evulate patients monthly during treatment with excimer light and minoxidil gel for three months With 20 patients who should completely recovered from alopecia areata.
- Secondary Outcome Measures
Name Time Method