Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

• Conditions: Ischaemic Stroke

• Registration Number: NCT01665729
• Lead Sponsor: Li Haiyan

Brief Summary

Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died. Therefore, diagnosis and treatment of minor ischaemic stroke according to the etiology and pathogenesis is important.

The 2007 Korean modified TOAST type got some progress, but there exists two major disadvantages: imperfect diagnosis and pathogenesis of perforator artery infarction etiology; lack of typing according to the pathogenesis of large atherosclerotic infarction and taking measures of treatment according to the new types. Recently, domestic professor Gaoshan proposes new approach to diagnose and treat minor ischaemic stroke according to the etiology and pathogenesis of CISS typing, but the pathogenesis of hypoperfusion infarction with severe stenosis of large artery is unclear. Is it low perfusion? Or artery-artery embolization? Or both? How to distinguish the pathogenesis of branch artery disease: by atherosclerosis? Or hyalinosis? Or both? How to check the validity of clinical types? This study take different interventions according to different types and observation of the long term clinical results of intervention( mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage), in order to clarify the new types can indeed solve the current problem of minor ischaemic stroke with high mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06
• Status Verified: 2012-08
• Primary Completion: 2012-08
• Study First Submitted: 2012-08-12
• Study First Submitted QC: 2012-08-14
• Last Update Submitted: 2012-08-14
• Study First Posted: 2012-08-15
• Last Update Posted: 2012-08-15
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

one of two conditions:

1. conscious patients with any of NIHSS score = 1,or
2. NIHSS ≤ 3

Exclusion Criteria

• patients Over 80 years of age
• patients With serious heart, lung, liver, kidney dysfunction or
• severe systemic complications,
• a known tumor,
• pregnancy,
• having a history of cerebral hemorrhage

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University; 🇨🇳 Guangzhou, Guangdong, China