Cortical Cerebellar Infarctions Associated With Patent Foramen Ovale in Young Stroke Patients

Completed

• Conditions: Brain Infarction
• Interventions: Other: MRI scanner; Other: Contrast transoesophageal echocardiography

• Registration Number: NCT04043559
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The investigator retrospectively analyzed consecutive young (\<60 years) cryptogenic stroke patients with Patient Foramen Ovale (PFO) recruited between January 2016 and May 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without PFO. Analyzed baseline characteristics: sex, age, cardiovascular risk factors, history of stroke, and cortical/subcortical localization, arterial territory, number of lesions, and lesion size of the acute symptomatic infarction, together with the ROPE score. The presence and the number of acute and chronic SCCI lesions were assessed.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-25
• Study First Submitted: 2019-07-25
• Study First Submitted QC: 2019-08-01
• Study First Posted: 2019-08-02
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-02
• Last Update Posted: 2021-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients : young (<60 years) adult patients,
• Patient recruited and registered in our stroke database between January 2016 and May 2016 of our center (Nîmes University Hospital, France),
• Patients presenting with an acute symptomatic infarction (confirmed by diffusion-weighted MRI) of unknown origin
• Controls : age-matched controls with cryptogenic stroke without PFO

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with an acute symptomatic infarction	MRI scanner	-
controls with cryptogenic stroke	Contrast transoesophageal echocardiography	-
patients with an acute symptomatic infarction	Contrast transoesophageal echocardiography	-
controls with cryptogenic stroke	MRI scanner	-

Primary Outcome Measures

Name	Time	Method
infarction location	day 1	anterior, posterior, or mixed anterior-posterior circulation and the cortical/subcortical/corticosubcortical location of infarction
number of infarction lesions	day 1	Number (increase)
size of subcortical lesion	day 1	\< or \>15mm
presence of multiterritorial infarction	day 1	mixed anterior-posterior circulation or bilateral anterior circulation

Trial Locations

Locations (1)

CHU Nîmes; 🇫🇷 Nîmes, France