Prevalence of Strokes Secondary to a Reversible Cerebral Vasoconstriction Attributable to Cannabis Consumption in Young Subjects (≤ 45 Years) Hospitalized for an Ischaemic Stroke

Not Applicable

Active, not recruiting

• Conditions: Stroke; Cannabis Use
• Interventions: Other: Drug urinal test

• Registration Number: NCT03379857
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Incidence of strokes has increased these last 20 years in young population. This rise could be linked to alcohol, tobacco or drug use like cannabis. Cannabis has previously been descripted as a potential factor of reversible vasoconstriction. The main objective is to show that an exhaustive assessment of a stroke facing a young person frequently lead to a diagnostic of reversible vasoconstriction due to cannabis use. Evaluation will focus on prevalence of strokes secondary to a reversible vasoconstriction attributable to cannabis in young subjects.

There's a real public healthcare interest in terms of primary and secondary prevention to evaluate the role of cannabis as a risk factor of stroke in young population.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-29
• Study First Submitted QC: 2017-12-19
• Study First Posted: 2017-12-20
• Study Start: 2018-01-11
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-19
• Last Update Posted: 2024-02-20
• Primary Completion: 2025-01-11
• Study Completion: 2025-01-11

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Subject between 18 and 45 years old
• Stroke confirmed by medical imaging
• Written informed consent (subject, nearby or emergency procedure)
• Subject affiliate to a local healthcare insurance office
• For female of childbearing potential, an adequate contraceptive measur

Exclusion Criteria

• Subject with psychiatric disorder, unable to understand the study or cooperate
• Subject under guardianship or forfeiture of liberty
• Pregnant or breastfeeding woman
• Subject in period of exclusion due to another study or still in follow-up of an interventional study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cannabis User	Drug urinal test	-

Primary Outcome Measures

Name	Time	Method
Evaluation Cannabis use	12 months
Reversible vasoconstriction on medical imaging of intracranial arteries at different moment	12 months.	medical imaging of intracranial arteries will show new stenoses (topography, number, evolution), and new ischemic or cerebral haemorrhagic lesions

Trial Locations

Locations (6)

Chu Jean Minjoz; 🇫🇷 Besancon, France

Unite Neuro-Vasculaire; 🇫🇷 Colmar, France

C.H. G. Muller; 🇫🇷 Mulhouse, France

Chu Bocage; 🇫🇷 Dijon, France

Hopital Central; 🇫🇷 Nancy, France

Les Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France