Intracranial Arterial Stenosis and Resin of Cannabis Use

Not Applicable

Recruiting

• Conditions: Cannabis Users
• Interventions: Other: Cerebral MRI and MRA

• Registration Number: NCT02246140
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

There is an association between intracranial arterial stenosis and ischemic stroke in young adults. The aim of this study is to evaluate the prevalence of intracranial arterial stenosis in asymptomatic regular resin of cannabis users in comparison with control subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-07
• Study First Submitted: 2014-09-17
• Study First Submitted QC: 2014-09-19
• Study First Posted: 2014-09-22
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-28
• Last Update Posted: 2024-08-29
• Primary Completion: 2026-08
• Study Completion: 2026-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• regular resin of cannabis users

Exclusion Criteria

• taking vasoactive medications
• taking other illicit drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cannabis users	Cerebral MRI and MRA	Cerebral MRI and MRA
healthy volunteers	Cerebral MRI and MRA	Cerebral MRI and MRA

Primary Outcome Measures

Name	Time	Method
Presence of intracranial arterial stenosis on cerebral MRA	3 months	Rate on cerebral MRA the presence of cerebral Intracranial Arterial Stenosis segmental narrowing defined by at least two intra-cranial arteries compared with a cohort of non cannabis controls subjects.

Secondary Outcome Measures

Name	Time	Method
-new intracranial arterial stenosis at 3 month follow-up	3 months	Evaluate a cerebral MRA at 3 months the presence of new intracranial stenosis among cannabis users, according to the prosecution or stopping use
-Silent ischemic stroke on cerebral MRI	3 months	Evaluate on cerebral MRI the presence of sequelae of ischemic stroke defined by a parenchymal hyperintensity in a vascular territory defined on a T2 sequence.
-Reversibility of intracranial arterial stenosis at 3 month follow-up	3 months	Evaluate on cerebral MRA at 3 months reversibility stenosis present at T0 in cannabis users having stopped their consumption

Trial Locations

Locations (1)

Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg,, France