Role of CCL2 in Alcoholic Liver Diseases
Completed
- Conditions
- Alcoholic Liver Disease
- Registration Number
- NCT01128010
- Lead Sponsor
- Erasme University Hospital
- Brief Summary
Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Excess alcohol intake
- Abnormality of liver biopsy compatible with alcoholic aetiology
- Caucasian ethnicity
Exclusion Criteria
- Presence of any other chronic liver disease
- co-infection with HIV Controls Inclusion criteria
- Caucasian ethnicity
- presence of a disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method