Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Completed

• Conditions: Alcoholic Liver Disease; Chronic Hepatitis C Virus

• Registration Number: NCT00610597
• Lead Sponsor: Erasme University Hospital

Brief Summary

Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Detailed Description

Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Study Timeline

• Study Start: 2005-01
• Primary Completion: 2007-01
• Status Verified: 2008-01
• Study Completion: 2008-01
• Study First Submitted: 2008-01-28
• Study First Submitted QC: 2008-01-28
• Last Update Submitted: 2008-01-28
• Study First Posted: 2008-02-08
• Last Update Posted: 2008-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

• Alcohol excess intake and suspected liver disease
• Alcohol excess intake and clinical liver cirrhosis
• chronic hepatitis C virus infection and suspected liver disease
• chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion Criteria

• bacterial or fungal infection
• immunosuppressive treatment
• other causes of liver disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Hopital Erasme - Dpt of Gastroenterology; 🇧🇪 Brussels, Belgium