Myopic Macular Haemorrhages

Completed

• Conditions: Myopic Macular Haemorrhages

• Registration Number: NCT00345228
• Lead Sponsor: Singapore National Eye Centre

Brief Summary

1. To identify the underlying causes of macular haemorrhages in patients with high myopia

2. In the eyes found to have macular haemorrhages secondary to choroidal neovascularisation, we hope to identify the risk factors for the development of choroidal neovascularisation in high myopia

3. To study the functional outcome of these eyes as assessed by visual acuity

4. To study the morphological outcome of these eyes by clinical assessment (and fundal photography) and fluorescein angiography

Detailed Description

Primary Aims

* To identify the underlying aetiologies of macular haemorrhages in myopic eyes

* To study the functional and morphological outcome of these eyes with macular haemorrhages 6 months later Secondary Aims

* To study the subgroup of eyes with myopic choroidal neovascularisation (CNV), in particular the risk factors for CNV in myopes

* To study the subgroup of eyes with macular haemorrhages in the absence of CNV

Plan of investigation:

1. Patient with myopia (\>-6.00DS) presents with loss of central vision

2. Examination reveals a macular haemorrhage

3. Investigations

* Refraction

* Axial length\*

* Fundus fluorescein angiography

* Indocyanine green angiography\*

4. Determine if a myopic CNV is present or absent

5. Management of patient: Treatment vs No treatment

* Treatment being

1. Conventional laser

2. PDT

6. Review at 6 months

* BCVA

* Clinical appearance (fundal photo)

* FFA

7. Review at 12 months

* BCVA

* Clinical appearance

Study Timeline

• Status Verified: 2004-05
• Study Start: 2004-06
• Study First Submitted: 2006-06-26
• Study First Submitted QC: 2006-06-26
• Last Update Submitted: 2006-06-26
• Study First Posted: 2006-06-27
• Last Update Posted: 2006-06-27
• Study Completion: 2006-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• High myopia (greater than -6.00DS)
• Macular haemorrhage

Exclusion Criteria

• Macular haemorrhages from other causes eg. diabetic retinopathy, hypertensive retinopathy
• Allergy to fluorescein or indocyanine green dyes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Singapore National Eye Centre; 🇸🇬 Singapore, Singapore