Angiotensin Converting Enzyme Inhibitors and Periprocedural Myocardial Infarction

Completed

• Conditions: Metabolic Syndrome; Coronary Artery Disease

• Registration Number: NCT02054390
• Lead Sponsor: Ankara University

Brief Summary

Metabolic syndrome (MS) has been reported as a risk for cardiovascular events. The aim of the present cohort study is to investigate whether ACEi therapy reduces the rate of periprocedural myocardial injury (PPMI) after elective percutaneous coronary intervention (PCI) among patients with metabolic syndrome.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-02-03
• Study First Submitted QC: 2014-02-03
• Study First Posted: 2014-02-04
• Status Verified: 2014-06
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Last Update Submitted: 2014-06-19
• Last Update Posted: 2014-06-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 459

Inclusion Criteria

1. metabolic syndrome
2. elective percutaneous coronary intervention with angiographically successful stent implantation

Exclusion Criteria

1. acute coronary events
2. renal failure
3. needed the use of IV glycoprotein IIb/IIIa receptor inhibitors were excluded
4. left main coronary artery disease
5. chronic total occlusion
6. high levels of baseline CKMB or troponin
7. any contraindication of aspirin, clopidogrel or ACEi treatment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Periprocedural myocardial injury (MI)	24 hours after (percutaneous coroary intervention) PCI	Periprocedural MI was defined as cardiac Troponin I release \[5 times ULN\] 24 hours after percutaneous coronary intervention

Secondary Outcome Measures

Name	Time	Method
Periprocedural myonecrosis	24 hours after PCI	Peri-procedural myonecrosis was defined as troponin I release of \>1×ULN 24 hours after the intervention.

Trial Locations

Locations (1)

Ankara University School Of Medicine, Department of Cardiology; 🇹🇷 Ankara, Turkey