Influence of Omega 3 fatty acids on osmosensation and thirst signaling

Phase 1

• Conditions: Improving dehydration in elderly by supplementation of Omega 3 fatty acids; Improving thirst sensation by supplementation of Omega 3 fatty acids; Improving quality of life by supplementation of Omega 3 fatty acids; Fluid intake; Public Health - Health promotion/education

• Registration Number: ACTRN12610000398000
• Lead Sponsor: Victoria University, Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-05-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

The participants who meet the following criteria will be included in the study
Age between 65 - 85y (inclusive) of both sex (ambulatory subjects).
Provide an informed consent

Exclusion Criteria

Mandatory exclusion criteria
Subjects who are included in any other clinical trials.
Abnormal kidney function, liver function and incomplete bladder control (enuresis).
Subjects on anticoagulant and diuretic medications.
Subjects with cardiac and/or chronic inflammatory conditions.
Subjects with hemorrhagic stroke and high diabetics conditions.
Allergy to fish products and currently on fish oil or flax seed supplements.
Subjects on fluid / salt restriction diet and severe cognitive impairment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Voluntary fluid intake with omega 3 fatty acid supplementation<br><br>Tool:Graduated bottled water will be provided to participants to monitor the daily volume of water consumption. This will be recorded in a nutrition diary in addition to all other fluids like tea, coffee, soup or juice etc for both intervention and placebo cohorts.[Thrice a week throughout for the entire study period of 3 months];Improving thirst sensation<br><br>Tool: Measured by a scored visual analogue scale, where the participants will be asked to mark a scale between 0-5 for both intervention and placebo cohorts. The thirst rating scale comprises of: 0 score- not at all thirsty, 1-slightly thirsty, 2-moderately thirsty, 3-strongly or very thirsty and 4-extremely thirsty and 5- severve thirst.[Measuring the thirst rates at the base line, in end of month 1, end of month 2 and end of month 3 at the blood sampling time and at 2 instance of thirst challenge with salt meal/drink for both cohorts.]

Secondary Outcome Measures

Name	Time	Method
Quality of life change with omega 3 fatty acid supplementation<br><br>Tools: Quality of life will assessment by SF-36 assessment tool for both cohorts. at the start of the trial ( month 1) and at the end of 3 month trial period for both cohorts.[Base line assessment of quality of life at the start of the trial (month 1) and at the end of 3 month trial period for both cohorts.]