Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development
- Registration Number
- NCT03044561
- Lead Sponsor
- Ain Shams University
- Brief Summary
The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF
- Detailed Description
sildenafil citrate may increase endometrial thickness in women with recurrent IVF failure attributed to poor endometrial development
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
- (1) cases of infertility, older than 20 years of age and not older than 40 years.
- (2) Body mass index (BMI):20-29.
- (3) women have experienced two or more implantation failure attributed to inadequate endometrial development.
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Exclusion Criteria
-
(1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome).
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(2) Any contraindication to sildenafil citrate or any of the components of its formulation including:
- Concurrent use of organic nitrites and nitrates.
- Severe hepatic impairment.
- Severe renal impairment.
- Hypotension.
- Recent stroke or heart attack.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sildenafil citrate Sildenafil Citrate - placebo matching placebo -
- Primary Outcome Measures
Name Time Method endometrial thickness measures 21 days we will measure endometrial thickness by US in women with recurrent implantation failure
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ain shams university
🇪🇬Cairo, Egypt