Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- estimate the result of sildenafil on ultrasonographic endometrial thickness
研究概览
简要总结
The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women > 40 years old,
- •history of endocrine disease
- •Hysteroscopic surgery
- •cardiovascular, renal and liver disease
- •hypotension( blood pressure < 90/50)
- •history of stroke or myocardial infarction
- •use of alcohol or substance
排除标准
- •A total of 80 patients with antecedent of poor endometrial response and had frozen embryo included in this study all women must to be < 40 years old,
- •no history of endocrine disease,
- •no Hysteroscopic surgery, had a high quality embryos no cardiovascular,
- •renal and liver disease and
- •no hypotension (blood pressure < 90/50) or
- •history of stroke or myocardial infarction and
- •don't use of alcohol or substance Patients with these conditions enter this study and based on randomized tables are divided in two groups.
研究组 & 干预措施
sildenafil
One of two group to prepare the endometrium give estradiol by step up method with menstruation.
From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily.
干预措施: Sildenafil (Drug)
Sildenafil and estradiol valerat
One of two group to prepare the endometrium give estradiol by step up method with menstruation.
From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily.
干预措施: Sildenafil (Drug)
Sildenafil and estradiol valerat
One of two group to prepare the endometrium give estradiol by step up method with menstruation.
From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily.
干预措施: estradiol valerat (Drug)
结局指标
主要结局
estimate the result of sildenafil on ultrasonographic endometrial thickness
时间窗: between 2009-2011 (up to 2 years)
Assays: Day 13 of menstrual cycle endometrial thickness estimated with Transvaginal ultrasonographic(arranged in a series every other day), evaluations were performed by a single investigator, If the endometrial thickness is more than 8mm progesterone injected 100 mg intramuscular and Estrogen, progesterone and lh measured in blood sample then after three days embryo transferred.
次要结局
- estimate the result of sildenafil on Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .(between 2009-2011 (up to 2 years))
研究者
farzaneh hojjat
Farzaneh hojjat MD
Shahid Sadoughi University of Medical Sciences and Health Services