Effect of sildenafil citrate on endometrial preparation and on the outcome of the frozen-thawed embryo transfer cycles

Phase 2

Conditions: Female Infertility.
Complications of attempted introduction of embryo in embryo transfer

Registration Number: IRCT201210232575N3

Lead Sponsor: Yazd Shahid Sadoughi University of Medical Sciences and Health Services, Vice Chancellor for resear

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 80

Inclusion Criteria

Inclusion criteria:
All infertile women have high quality frozen embryos.

Exclusion criteria:
1. Age> 40
2. History of endocrine disease such as: diabetes; Hyperthyroidism and Hyperprolactinemia
3. History of hysteroscopic surgery due to intrauterine adhesions
4. History of cardiovascular, renal or liver disease
5. Hypotension( blood pressure<90/50)
6. History of stroke or myocardial infarction
7. Poor quality embryos
8. Alcohol or Substance abuse

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endometrial thickness. Timepoint: ?Within a day from 13th day of the menstrual cycle. Method of measurement: Vaginal sonoghraphy.;Chemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: BHCG test.

Secondary Outcome Measures

Name	Time	Method
Duration of infertility. Timepoint: Before intervention. Method of measurement: Patient's medical record.;Implantation rate. Timepoint: Four weeks after the embryo transfer. Method of measurement: Number of gestational sac are determined by vaginal ultrasound.;FSH, LH, FSH/LH level. Timepoint: ratio in progesterone day administration. Method of measurement: Blood sample.